KIRA9
KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2922507-65-9
- Formula: C27H27F3N6O3S
- Molecular Weight:572.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 4.8 μM (IRE1) in INS-1 cells[1]
KIRA9 (0-30 μM; 2 hours) blocks the autophosphorylation induced by conditional overexpression of IRE1α in INS-1 cells (IC50=4.8 μM)[1].
KIRA9 (20 μM; 2 hours) reduces the mRNA expression of Bloc1s1, Ins1 and Ins2 in INS-1 cells[1].
KIRA9 (20 μM; 2 hours) blunts IRE1α-dependent decay (RIDD) in ER-stressed INS-1 cells[1].
KIRA9 (20 μM; 1 hour) markedly reduces the generation of cleaved caspase-3 and shows significant cytoprotective efficacy[1].
KIRA9 (0-20 μM; 3 days) reduces XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:INS-1 cells[1]
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Concentration:20 μM
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Incubation Time:1 hour
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Result:Markedly reduced the generation of cleaved caspase-3 and showed significant cytoprotective efficacy.
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Cell Line:Mouse splenocytes (LPS-treated)[1]
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Concentration:0, 1.25, 2.5, 5.0, 10 and 20 μM
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Incubation Time:3 days
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Result:Reduced XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner.
Chemical Information
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CAS No. 2922507-65-9
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Molecular Weight 572.60
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Formula C27H27F3N6O3S
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SMILES
O=S(NC1=CC=C(OC2=NC=CC=C2C3=CC=NC(N[C@@H]4CNCCC4)=N3)C5=C1C=CC=C5)(CCC(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KIRA9 Related Classifications
HY-145422 Related Classifications
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