Closantel (sodium)
Based on 12 publication(s) in Google Scholar
Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.69%
- CAS 番号: 61438-64-0
- 分子式: C22H13Cl2I2N2NaO2
- 分子量:685.06
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Closantel sodium
More- Autophagy. 2026 Mar 5. [Abstract]
- Acta Pharm Sin B. 2025 Mar;15(3):1535-1551. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- J Mol Cell Biol. 2023 Aug 3;15(3):mjad017. [Abstract]
- Cancers (Basel). 2020 Mar 2;12(3):575. [Abstract]
- J Biol Chem. 2022 Oct;298(10):102417. [Abstract]
- Microbiologyopen. 2025 Oct;14(5):e70062. [Abstract]
- Preprints. 2026 Jun 19.
- Drug Repurposing. 2026 Jan 30.
- bioRxiv. 2025 March 01.
- Università Vita-Salute San Raffaele. 2022 Apr 08. 34.
- L’UNIVERSITE GRENOBLE ALPES. 2021 Apr 13.
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生物活性
製品説明
体外実験
Closantel sodium, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 61438-64-0
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性状 Solid
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分子量 685.06
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分子式 C22H13Cl2I2N2NaO2
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Color White to yellow
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SMILES
O=C(NC1=CC(Cl)=C(C(C2=CC=C(Cl)C=C2)C#N)C=C1C)C3=CC(I)=CC(I)=C3O[Na]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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Autophagy
2026 Mar 5. PMID: 41787744 -
Acta Pharm Sin B
2025 Mar;15(3):1535-1551. PMID: 40370558
Closantel sodium purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Mar;15(3):1535-1551. [Abstract]
HEK293T cells were pretreated with 20 μmol/L Closantel for 1 h and then infected with indicated MOI HSV-1 for 24 h. HSV-1 RNA replicates were detected by qPCR.
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
J Mol Cell Biol
2023 Aug 3;15(3):mjad017. PMID: 36921991 -
Cancers (Basel)
2020 Mar 2;12(3):575. PMID: 32131390
Closantel sodium purchased from MedChemExpress. Usage Cited in: Cancers (Basel). 2020 Mar 2;12(3):575. [Abstract]
Representative images of embryos before and after treated with DMSO (vehicle), PTK787, WNK463 or Closantel (0.15 μM).
Closantel sodium purchased from MedChemExpress. Usage Cited in: Cancers (Basel). 2020 Mar 2;12(3):575. [Abstract]
Representative H&E-stained sections of intestinal tract of RPIA transgenic fish treated with Closantel (1.5 μM).
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J Biol Chem
α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention. [Abstract]2022 Oct;298(10):102417. PMID: 36037967 -
Microbiologyopen
2025 Oct;14(5):e70062. PMID: 40926309 -
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溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (182.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
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- Italian - IT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72. [Content Brief]
[2]. G E Swan, et al. The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc. 1999 Jun;70(2):61-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4597 mL | 7.2986 mL | 14.5973 mL | 36.4932 mL |
| 5 mM | 0.2919 mL | 1.4597 mL | 2.9195 mL | 7.2986 mL | |
| 10 mM | 0.1460 mL | 0.7299 mL | 1.4597 mL | 3.6493 mL | |
| 15 mM | 0.0973 mL | 0.4866 mL | 0.9732 mL | 2.4329 mL | |
| 20 mM | 0.0730 mL | 0.3649 mL | 0.7299 mL | 1.8247 mL | |
| 25 mM | 0.0584 mL | 0.2919 mL | 0.5839 mL | 1.4597 mL | |
| 30 mM | 0.0487 mL | 0.2433 mL | 0.4866 mL | 1.2164 mL | |
| 40 mM | 0.0365 mL | 0.1825 mL | 0.3649 mL | 0.9123 mL | |
| 50 mM | 0.0292 mL | 0.1460 mL | 0.2919 mL | 0.7299 mL | |
| 60 mM | 0.0243 mL | 0.1216 mL | 0.2433 mL | 0.6082 mL | |
| 80 mM | 0.0182 mL | 0.0912 mL | 0.1825 mL | 0.4562 mL | |
| 100 mM | 0.0146 mL | 0.0730 mL | 0.1460 mL | 0.3649 mL |
Closantel sodium 関連分類
HY-17596A 関連分類
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