Homatropine (methylbromide)
Based on 1 Customer Validation
Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 80-49-9
- 分子式: C17H24BrNO3
- 分子量:370.28
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: WKY-E (162.5 nM), SHR-E (170.4 nM)
Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 80-49-9
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性状 Solid
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分子量 370.28
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分子式 C17H24BrNO3
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Color White to off-white
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SMILES
C[N+]1([C@@H]2C[C@@H](OC(C(O)C3=CC=CC=C3)=O)C[C@H]1CC2)C.[Br-]
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別名
Homatropine methobromide; 臭化メチルホマトロピン
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (270.07 mM)
DMSO : ≥ 31 mg/mL (83.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens. 1993 Mar;15(2):409-21. [Content Brief]
[2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9. [Content Brief]
[3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80(1):11-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.7007 mL | 13.5033 mL | 27.0066 mL | 67.5165 mL |
| 5 mM | 0.5401 mL | 2.7007 mL | 5.4013 mL | 13.5033 mL | |
| 10 mM | 0.2701 mL | 1.3503 mL | 2.7007 mL | 6.7516 mL | |
| 15 mM | 0.1800 mL | 0.9002 mL | 1.8004 mL | 4.5011 mL | |
| 20 mM | 0.1350 mL | 0.6752 mL | 1.3503 mL | 3.3758 mL | |
| 25 mM | 0.1080 mL | 0.5401 mL | 1.0803 mL | 2.7007 mL | |
| 30 mM | 0.0900 mL | 0.4501 mL | 0.9002 mL | 2.2505 mL | |
| 40 mM | 0.0675 mL | 0.3376 mL | 0.6752 mL | 1.6879 mL | |
| 50 mM | 0.0540 mL | 0.2701 mL | 0.5401 mL | 1.3503 mL | |
| 60 mM | 0.0450 mL | 0.2251 mL | 0.4501 mL | 1.1253 mL | |
| 80 mM | 0.0338 mL | 0.1688 mL | 0.3376 mL | 0.8440 mL | |
| H2O | 100 mM | 0.0270 mL | 0.1350 mL | 0.2701 mL | 0.6752 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Homatropine (methylbromide) 関連分類
HY-B1388 関連分類
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