TGF-beta/Smad Agonist

SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects, with blood-brain barrier permeability.

IDE 2 is a cell-permeable inducer of definitive endoderm differentiation that induces the differentiation of mouse and human embryonic stem cells into definitive endoderm. IDE2 activates the TGF‑β/Nodal signaling pathway, induces Smad2 phosphorylation, and increases Sox17 and FoxA2 expression. Endoderm induced by IDE 2 integrates into the developing gut tube, expresses gut tube markers, and differentiates into pancreatic progenitor cells. IDE 2 can be used for research related to directed endoderm differentiation of embryonic stem cells.

SRI-011381 (hydrochloride) (Standard) is the analytical standard of SRI-011381 (hydrochloride) (HY-100347A). This product is intended for research and analytical applications. SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer.

SRI-011381 (Standard) is the analytical standard of SRI-011381 (HY-100347). This product is intended for research and analytical applications. SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

SRI-011381-d₅ is the deuterium labeled SRI-011381 (HY-100347). SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.