AGL 2043
AGL 2043 is an effective inhibitor of PDGFR (IC50=0.8 μM) and TEL-PDGFR kinases, as well as FLT3 and KIT kinases. AGL 2043 can effectively inhibit porcine cardiac smooth muscle cell proliferation and balloon-induced vascular stenosis, and is suitable for development as an anti-restenotic and anticancer agent.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 226717-28-8
- 分子式: C15H12N4S
- 分子量:280.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 0.8 μM (PDGFR)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
1 μM
Compound: 27; AGL 2043
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Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimulation by immunoblot analysis
Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimulation by immunoblot analysis
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[PMID: 30502116] |
| NIH3T3 | IC50 |
>30 μM
Compound: 27; AGL 2043
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Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assay
Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assay
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[PMID: 30502116] |
化学情報
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CAS 番号 226717-28-8
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分子量 280.35
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分子式 C15H12N4S
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SMILES
CC(N1C)=NC2=C1C=C3N=CC(C4=CC=CS4)=NC3=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AGL 2043 関連分類
HY-112350 関連分類
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