AM-36
AM-36 is a neuroprotective agent with combined antioxidant and sodium channel blocking actions. AM-36 can inhibit cell apoptosis and ROS prodiction. AM-36 can reduce neuronal damage and DA release after middle cerebral artery occlusion in rats. AM-36 can be used for the researches of inflammation and neurological disease, such as stroke.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 199467-52-2
- 分子式: C27H39ClN2O2
- 分子量:459.06
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
AM-36 (0.01-10 μM) completely inhibits Veratridine (HY-N6691)-induced toxicity (IC50 = 1.5-1.9 μM) and inhibits apoptosis in cerebellar granule cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Middle cerebral artery occlusion (MCAO) rats[1]
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Dosage:6 mg/kg
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Administration:Intraperitoneally injection, 30, 60 and 180 mins after MCAO
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Result:Reduced cortical damage and neuronal damage.
Reduced Striatal damage treated with AM-36 at 180 mins.
化学情報
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CAS 番号 199467-52-2
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分子量 459.06
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分子式 C27H39ClN2O2
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SMILES
ClC1=CC=C(C(CN2CCN(CC2)CC3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Callaway JK, et al. Delayed treatment with AM-36, a novel neuroprotective agent, reduces neuronal damage after endothelin-1-induced middle cerebral artery occlusion in conscious rats. Stroke. 1999 Dec;30(12):2704-12; discussion 2712. [Content Brief]
[2]. Callaway JK, et al. Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis. Br J Pharmacol. 2001 Apr;132(8):1691-8. [Content Brief]
[3]. Callaway JK, et al. AM-36, a novel neuroprotective agent, profoundly reduces reactive oxygen species formation and dopamine release in the striatum of conscious rats after endothelin-1-induced middle cerebral artery occlusion. Neuropharmacology. 2003 May;44(6):787-800. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AM-36 関連分類
HY-114659 関連分類
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