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製品番号: HY-18052

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AM-8553

AM-8553 is a MDM2/p53 inhibitor (K_D: 0.4 nM for MDM2). AM-8553 has anti-tumor activity

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CAS 番号: 1352064-70-0
分子式: C₂₅H₂₉Cl₂NO₄
分子量:478.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AM-8553 構造式

CAS 番号: 1352064-70-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

AM-8553 is a MDM2/p53 inhibitor (K_D: 0.4 nM for MDM2). AM-8553 has anti-tumor activity^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>25 μM Compound: 29, AM-8553	Antiproliferative activity against p53 deficient human HCT116 cells assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry Antiproliferative activity against p53 deficient human HCT116 cells assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry	[PMID: 22524527]
HCT-116	IC₅₀	0.2 μM Compound: 29, AM-8553	Antiproliferative activity against human HCT116 cells expressing wild type p53 assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry Antiproliferative activity against human HCT116 cells expressing wild type p53 assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry	[PMID: 22524527]
SJSA-1	ED₅₀	78 mg/kg Compound: 29, AM-8553	Antitumor activity against human SJSA1 cells xenografted in po dosed athymic nude mouse assessed as tumor growth inhibition administered qd after 14 days Antitumor activity against human SJSA1 cells xenografted in po dosed athymic nude mouse assessed as tumor growth inhibition administered qd after 14 days	[PMID: 22524527]
SJSA-1	IC₅₀	0.068 μM Compound: 29, AM-8553	Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation assay in presence of 10% human serum	[PMID: 22524527]
SJSA-1	IC₅₀	0.073 μM Compound: 1, AM-8553	Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation-based HCS assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation-based HCS assay in presence of 10% human serum	[PMID: 25147610]
SJSA-1	IC₅₀	0.76 μM Compound: 29, AM-8553	Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum	[PMID: 22524527]
SJSA-1	IC₅₀	72 nM Compound: 1, AM-8553	Antiproliferative activity against human SJSA1 cells assessed as inhibition of EdU incorporation after 1 hr by Click-iT EdU HCS assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells assessed as inhibition of EdU incorporation after 1 hr by Click-iT EdU HCS assay in presence of 10% human serum	[PMID: 24456472]
SJSA-1	IC₅₀	760 nM Compound: 1, AM-8553	Antiproliferative activity against human SJSA1 cells assessed as induction of p21 gene level by qRT-PCR assay in presence of 10% human serum Antiproliferative activity against human SJSA1 cells assessed as induction of p21 gene level by qRT-PCR assay in presence of 10% human serum	[PMID: 24456472]

化学情報

CAS 番号 1352064-70-0
分子量 478.41
分子式 C₂₅H₂₉Cl₂NO₄
SMILES

O=C(O)C[C@]1(C)C(N([C@@H](CC)[C@@H](O)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bernard D, et al. AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development. J Med Chem. 2012 Jun 14;55(11):4934-5. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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