Antimicrobial agent-52
Antimicrobial agent-52 is a broad-spectrum Bactericide. Antimicrobial agent-52 exerts rapid bactericidal effects against Gram-positive and Gram-negative pathogenic bacteria. Antimicrobial agent-52 exhibits activity against Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli. Antimicrobial agent-52 can be used in the research of bacterial infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H20N2O6
- 分子量:456.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Antimicrobial agent-52 (24 h) exhibits bactericidal activity in vitro against Staphylococcus aureus (MBC = 1.56 μM), Klebsiella pneumoniae (MBC = 0.19 μM), Acinetobacter baumannii (MBC = 1.56 μM), and Escherichia coli (MBC = 0.04 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7, J774A.1, HEK293
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Concentration:6.25-200 μM
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Incubation Time:20 h (with compound); 4 h (with MTT)
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Result:Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for RAW 264.7 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for J774A.1 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~44%, ~70%, ~87%, ~88%, ~93%, and ~96% for HEK293 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Calculated CC50 values were 42.27 μM for RAW 264.7, 49.58 μM for J774A.1, and 200 μM for HEK293.
Achieved Selectivity Index (SI) values ranging from 48.03 to 2113.5 for RAW 264.7, 56 to 2479 for J774A.1, and 227.27 to 10,000 for HEK293 against the four bacterial strains.
化学情報
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分子量 456.45
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分子式 C26H20N2O6
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C1C(OCC4=CC(C5=NC=CC=C5)=NO4)=C(OC)C(OC)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimicrobial agent-52 関連分類
HY-184904 関連分類
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Keywords
- Antimicrobial agent-52
- Antimicrobial agent52
- Antimicrobial agent 52
- Bacterial
- outer membrane protein A
- Gram-positive bacterial pathogens
- Gram-negative bacterial pathogens
- Staphylococcus aureus
- extended-spectrum β-lactamase
- Klebsiella pneumoniae
- Escherichia coli
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate ligase
- clumping factor A
- Acinetobacter baumannii
- Inhibitor
- inhibitor
- inhibit