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製品番号: HY-146172

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Antioxidant agent-3

Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS⁺ scavenging activity with IC₅₀s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H₂O₂-treated HepG2 cells.

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CAS 番号: 2710376-48-8
分子式: C₁₈H₁₄O₈
分子量:358.30

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antioxidant agent-3 構造式

CAS 番号: 2710376-48-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS + scavenging with the values of IC₅₀ is 26.58 μM and 30.31 μM respectively^[1].
Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC₅₀ > 100 μM) and GES (IC₅₀ > 200 μM) cells^[1].
Antioxidant agent-3 can enhance viability of H₂O₂-induced HepG2 cells^[1].
Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells^[1].
Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H₂O₂-treated HepG2 cells, and exhibits more stability in methanol solution^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

WI-38 and GES cells line
Concentration:

200, 100, 50, 25 and 12.5 μM
Incubation Time:

48 h
Result:

Showed less toxicity in hemolysis assay and weaker antiproliferative effects.

Cell Viability Assay^[1]

Cell Line:

H₂O₂-damaged WI-38 and HepG2 cells
Concentration:

50, 25 and 12.5 μM
Incubation Time:

1 h
Result:

Increased cells viability of H2O2-indcued cells and protected the H2O2-indcued cells against injury.

Apoptosis Analysis^[1]

Cell Line:

H₂O₂-damaged HepG2 cells
Concentration:

50, 25 and 12.5 μM
Incubation Time:

1 h
Result:

Protect the H₂O₂-injured HepG2 cells against apoptosis through antioxidant effect.

化学情報

CAS 番号 2710376-48-8
分子量 358.30
分子式 C₁₈H₁₄O₈
SMILES

O=C(C(C1=O)=CC2=C(O1)C(O)=C(O)C=C2)OCCC3=CC=C(O)C(O)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wen-Bo Li, et al.Synthesis and antioxidant activity of conjugates of hydroxytyrosol and coumarin. Bioorg Chem. 2020 Dec;105:104427. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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