Antitumor agent-102
Antitumor agent-102 (compound 10) is a conjugate of Topoisomerase I inhibitor SN38 and glucose transporter inhibitor, targeting to colorectal cancer. Antitumor agent-102 induces higher concentrations of free SN38 in tumor tissues than Irinotecan (HY-16562).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2956876-32-5
- 分子式: C70H82N8O18S
- 分子量:1355.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
4.59 μM
Compound: 10
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Cytotoxicity against human COLO 205 cells incubated for 48 hrs by SRB assay
Cytotoxicity against human COLO 205 cells incubated for 48 hrs by SRB assay
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[PMID: 37413981] |
| HCT-116 | IC50 |
7.43 μM
Compound: 10
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Cytotoxicity against human HCT-116 cells incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by SRB assay
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[PMID: 37413981] |
| HT-29 | IC50 |
>100 μM
Compound: 10
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Cytotoxicity against human HT-29 cells incubated for 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells incubated for 48 hrs by SRB assay
|
[PMID: 37413981] |
化学情報
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CAS 番号 2956876-32-5
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分子量 1355.51
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分子式 C70H82N8O18S
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SMILES
O=C(N1CCCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC3=CC=C(C4=C3)N=C5C(N6CC5=C4CC)=CC([C@@](CC)7O)=C(C6=O)COC7=O)=O)CCCNC(N)=O)=O)C(C)C)=O)C(SCCOCCOCCOC8=CC(O)=C(C(O)=C8)C(CCC9=CC=C(C=C9)O)=O)CC1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-102 関連分類
HY-155034 関連分類
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