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製品番号: HY-147897

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Apoptosis inducer 9

Apoptosis inducer 9 induces apoptosis with IC₅₀ value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents.

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CAS 番号: 2551067-10-6
分子式: C₃₄H₅₅N₃O₄S
分子量:601.88

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Apoptosis inducer 9 構造式

CAS 番号: 2551067-10-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Apoptosis inducer 9 (Compound A1) (5-10 μM, 12 hours) induces apoptosis in HepG-2 cells in a concentration-dependent manner^[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) triggers Cl-caspase-3, Cl-caspase-9 and Cl-PARP protein expression in HepG-2, thereby inducing apoptosis^[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) induces apoptosis by triggering the mitochondrial apoptosis pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG-2 cells
Concentration:

5 and 10 μM
Incubation Time:

12 hours
Result:

Apoptotic bodies appeared shrunken, nuclei shrunken and cells fragmented. The apoptosis rates at concentrations of 5 μM and 10 μM were 10.2% and 42.7%, respectively.

Western Blot Analysis^[1]

Cell Line:

HepG-2 cells
Concentration:

0, 5, 10 and 20 μM
Incubation Time:

24 hours
Result:

Triggered the caspase cascade in HepG-2 and the corresponding protein expression gradually increased.

Western Blot Analysis^[1]

Cell Line:

HepG-2 cells
Concentration:

0, 5, 10 and 20 μM
Incubation Time:

24 hours
Result:

Induced up-regulation of the expression of Bcl-2, Bax and p53 proteins, and increased the ratio of Bax/Bcl-2.

化学情報

CAS 番号 2551067-10-6
分子量 601.88
分子式 C₃₄H₅₅N₃O₄S
SMILES

C[C@]12[C@@](C[C@H]([C@@]3([H])[C@]2(CC[C@]3([H])[C@@]4(OC(C)(CCC4)C)C)C)O)([H])[C@@]5([C@@](C(C)([C@H](CC5)OC(CSC6=NN=CN6)=O)C)([H])CC1)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xiao S, et al. Novel panaxadiol triazole derivatives induce apoptosis in HepG-2 cells through the mitochondrial pathway. Bioorg Chem. 2020 Sep;102:104078. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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