ARC 239 (Standard)
ARC 239 Standard is the analytical standard of ARC 239 (HY-12709). This product is intended for research and analytical applications. ARC 239 is a selective α2B/C-adrenoceptor antagonist, with pKi values of 5.45, 7.06, and 6.95 for α2A, α2B, and α2C receptors, respectively. ARC 239 selectively antagonizes α2B-AR, blocking norepinephrine signaling and downstream RhoA/ROCK activation and Claudin-5 disruption, without altering plasma norepinephrine levels in the distal tail artery of mice, and does not inhibit α2-adrenoceptor-mediated vasoconstriction. ARC 239 also binds with high affinity to 5-HT1A receptors, with a Ki of 63.1 nM, thereby interfering with subtype-selective α2-adrenoceptor assays. ARC 239 can be used for research on cardiovascular diseases and inflammatory skin diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 67339-62-2
- 分子式: C24H29N3O3
- 分子量:407.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 67339-62-2
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分子量 407.51
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分子式 C24H29N3O3
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SMILES
O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ARC 239 (Standard) 関連分類
HY-12709R 関連分類
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Keywords
- ARC 239 (Standard)
- 67339-62-2
- Reference Standards
- Adrenergic Receptor
- 5-HT Receptor
- ROCK
- Claudin
- Beta Receptor
- Serotonin Receptor
- 5-hydroxytryptamine Receptor
- Rho-associated protein kinase
- Rho-associated kinase
- Rho-kinase
- ROK
- 5-HT1A receptor
- Claudin-5
- RhoA
- human saphenous vein
- noradrenaline
- vascular leakage
- α1-adrenoceptor
- α2-adrenoceptor
- α2B-adrenoceptor
- Inhibitor
- inhibitor
- inhibit