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製品番号: HY-116031

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ATC0175 free base

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC₅₀ value of 3.4 nM, as well as good selectivity over the Y5 and the α_2A receptors. ATC0175 (free base) is promising for research of obesity.

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CAS 番号: 509118-03-0
分子式: C₂₃H₂₅F₂N₅O
分子量:425.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

ATC0175 free base 構造式

CAS 番号: 509118-03-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	8.28 nM Compound: ATC-0175	Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay	[PMID: 31678007]
COS-1	IC₅₀	260 nM Compound: 28 (ATC-O175)	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	[PMID: 16002290]
COS-1	IC₅₀	2700 nM Compound: 28 (ATC-O175)	Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells	[PMID: 16002290]
HEK293	IC₅₀	3.4 nM Compound: 28 (ATC-O175)	Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells	[PMID: 16002290]
HEK293	IC₅₀	7.2 nM Compound: ATC-0175	Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay	[PMID: 19773162]

化学情報

CAS 番号 509118-03-0
分子量 425.47
分子式 C₂₃H₂₅F₂N₅O
SMILES

CN(C1=NC(N[C@H]2CC[C@H](CC2)NC(C3=CC(F)=C(C=C3)F)=O)=NC4=C1C=CC=C4)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Eur Arch Psychiatry Clin Neurosci

Genetic factors and symptom dimensions associated with antidepressant treatment outcomes: clues for new potential therapeutic targets?. [Abstract]

2024 Aug 27. PMID: 39191930

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kanuma K, et al. Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ATC0175 free base

1 Cited Publications

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生物活性
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化学情報
Publications (1)
純度とドキュメンテーション
参考文献

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ATC0175 free base

MedChemExpress（MCE）の使用を引用している文献 ATC0175 free base

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

ATC0175 free base 関連分類

HY-116031 関連分類