ATIC-IN-1
Based on 1 publication(s) in Google Scholar
ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates.
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- CAS 番号: 1402453-15-9
- 分子式: C21H33N7O5
- 分子量:463.53
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 ATIC-IN-1
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生物活性
Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)[1]
ATIC-IN-1 (10 μM, 50 μM) is a specific inhibitor, and shows nonspecific aggregate mechanism in the present of 1 mg/mL and 10 mg/mL BSA[1].
ATIC-IN-1 (100-500 μM; 48 h) inhibits the proliferation of MCF-7 cells[1].
ATIC-IN-1 (250 μM; 24-72 h) results the reduction of division rather than leads to cell death increase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:100 μM, 250 μM, 500 μM
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Incubation Time:0 h, 24 h, 48 h, and 72 h
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Result:Reduced the division rate to inhibit MCF-7 proliferation at 250 μM.
化学情報
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CAS 番号 1402453-15-9
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性状 Solid
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分子量 463.53
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分子式 C21H33N7O5
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Color White to off-white
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SMILES
N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Am J Physiol Cell Physiol
Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. [Abstract]2025 Nov 1;329(5):C1560-C1576. PMID: 41071646
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ATIC-IN-1 関連分類
HY-150252 関連分類
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