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製品番号: HY-119548

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Bifidenone

Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines.

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CAS 番号: 2078008-57-6
分子式: C₂₁H₂₆O₅
分子量:358.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Bifidenone 構造式

CAS 番号: 2078008-57-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	0.075 μM Compound: 2	Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
ACHN	IC₅₀	0.36 μM Compound: 2	Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
HCC 2998	IC₅₀	1.41 μM Compound: 2	Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay	[PMID: 28335606]
M14	IC₅₀	0.064 μM Compound: 2	Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
M14	IC₅₀	0.11 μM Compound: 4a	Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay	[PMID: 29995409]
Malme-3M	IC₅₀	<0.1 μM Compound: 2	Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay	[PMID: 28335606]
MDA-MB-435	IC₅₀	<0.1 μM Compound: 2	Antiproliferative activity against human MDA-MB-435 cells after SRB assay Antiproliferative activity against human MDA-MB-435 cells after SRB assay	[PMID: 28335606]
NCI/ADR-RES	IC₅₀	0.17 μM Compound: 2	Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay	[PMID: 28335606]
NCI-H460	IC₅₀	0.26 μM Compound: 2	Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
NCI-H460	IC₅₀	0.26 μM Compound: 4a	Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay	[PMID: 29995409]
PC-3	IC₅₀	0.49 μM Compound: 2	Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
RAW264.7	IC₅₀	>5 μM Compound: 2	Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SF-295	IC₅₀	0.25 μM Compound: 2	Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SK-MEL-2	IC₅₀	0.095 μM Compound: 2	Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SR	IC₅₀	<0.1 μM Compound: 2	Antiproliferative activity against human SR cells after 48 hrs by SRB assay Antiproliferative activity against human SR cells after 48 hrs by SRB assay	[PMID: 28335606]
UACC-62	IC₅₀	0.044 μM Compound: 2	Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]

化学情報

CAS 番号 2078008-57-6
分子量 358.43
分子式 C₂₁H₂₆O₅
SMILES

O=C1C=C2OCO[C@]2(C[C@@H]1CC=C)[C@H](CC3=CC=C(C(OC)=C3)OC)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Huang Z, Williams RB, O'Neil-Johnson M, Eldridge GR, Mangette JE, Starks CM. A Total Synthesis of Bifidenone. J Org Chem. 2017 Apr 21;82(8):4235-4241. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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