BMS 310705
Based on 1 Customer Validation
BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B (HY-17029), targeting to malignancies such as ovarian, renal, bladder, and lung carcinoma. BMS 310705 induces significant apoptosis via mitochondrial-mediated pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.59%
- CAS 番号: 280578-49-6
- 分子式: C27H42N2O6S
- 分子量:522.70
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
BMS 310705 (0.01-0.5 μM; 1 h) induces cell apoptosis in OC-2 cells[1].
BMS 310705 (0.5 μM; 1 h) increases the activity of caspase-9 and -3, and leads to cytochrome c release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:OC-2 cells
-
Concentration:0.01 μM, 0.025 μM, 0.05 μM, and 0.5 μM
-
Incubation Time:1 hour; reincubation in drug-free media at 24-, 48-, 72-, and 96-h intervals
-
Result:Induced maximal cell apoptosis at 0.05 μM, and exhibited time-dependent manner.
化学情報
-
CAS 番号 280578-49-6
-
性状 Solid
-
分子量 522.70
-
分子式 C27H42N2O6S
-
Color Off-white to light yellow
-
SMILES
C[C@@]12[C@H](C[C@H](OC(C[C@@H](C(C)(C)C([C@H](C)[C@@H](O)[C@@H](C)CCC2)=O)O)=O)/C(C)=C/C3=CSC(CN)=N3)O1
-
別名
21-Aminoepothilone B
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (191.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.78 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
-
データシート (278 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9131 mL | 9.5657 mL | 19.1314 mL | 47.8286 mL |
| 5 mM | 0.3826 mL | 1.9131 mL | 3.8263 mL | 9.5657 mL | |
| 10 mM | 0.1913 mL | 0.9566 mL | 1.9131 mL | 4.7829 mL | |
| 15 mM | 0.1275 mL | 0.6377 mL | 1.2754 mL | 3.1886 mL | |
| 20 mM | 0.0957 mL | 0.4783 mL | 0.9566 mL | 2.3914 mL | |
| 25 mM | 0.0765 mL | 0.3826 mL | 0.7653 mL | 1.9131 mL | |
| 30 mM | 0.0638 mL | 0.3189 mL | 0.6377 mL | 1.5943 mL | |
| 40 mM | 0.0478 mL | 0.2391 mL | 0.4783 mL | 1.1957 mL | |
| 50 mM | 0.0383 mL | 0.1913 mL | 0.3826 mL | 0.9566 mL | |
| 60 mM | 0.0319 mL | 0.1594 mL | 0.3189 mL | 0.7971 mL | |
| 80 mM | 0.0239 mL | 0.1196 mL | 0.2391 mL | 0.5979 mL | |
| 100 mM | 0.0191 mL | 0.0957 mL | 0.1913 mL | 0.4783 mL |
BMS 310705 関連分類
HY-107020 関連分類
Powered by Bioz