BuChE-IN-7
BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC50 values of 40 nM, 80 nM respectively. BuChE-IN-7 can promote cognitive with blood-brain penetration and improves situational and phobic memory, showing preference for new things.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3041971-93-8
- 分子式: C25H34N2O2
- 分子量:394.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
hBCHE 40 nM (IC50) |
eqBCHE 80 nM (IC50) |
体外実験
BuChE-IN-7 (compound (R)-29) (10 µM; 5 min) inhibits eqBuChE, hBuChE with IC50 values of 0.08 µM, 0.04 µM respectively[1].
BuChE-IN-7 (1, 10, 50 and 100 µM; 72 h) has hepatotoxicity in HepG2 cell line with an IC50 value of 2.85 µM. BuChE-IN-7 decreas the cell activity and shows weaker effect on CYP3A4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
BuChE-IN-7 (10 mg/kg; i.p.; once daily for 6 days) has insignificant improvement the learning defect caused by scopolamine in mice[1].
BuChE-IN-7 (15 mg/kg and 30 mg/kg; i.p.; single dose) significantly promotes cognition and improves situational and phobic memory of mice, showing preference for new things[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3041971-93-8
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分子量 394.55
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分子式 C25H34N2O2
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SMILES
O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)NC[C@H](O)CNCC3CCCCC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BuChE-IN-7 関連分類
HY-152632 関連分類
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