Ceritinib dihydrochloride (Standard)
Ceritinib (LDK378) dihydrochloride (Standard) is the analytical standard of Ceritinib dihydrochloride (HY-15656A). This product is intended for research and analytical applications. Ceritinib dihydrochloride is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98%
- CAS 番号: 1380575-43-8
- 分子式: C28H38Cl3N5O3S
- 分子量:631.06
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
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HY-15656
CeritinibALK Inhibitor -
HY-15656A
Ceritinib dihydrochlorideALK Inhibitor -
HY-12215
LorlatinibALK/ROS1 Inhibitor -
HY-12678
EntrectinibTrk/ROS1/ALK Inhibitor -
HY-13011
AlectinibALK Inhibitor -
HY-10192
NVP-TAE 684ALK Inhibitor -
HY-15656R
Ceritinib (Standard)Insulin Receptor Inhibitor -
HY-12273
DMH-1BMP Inhibitor -
HY-12071
LDN193189ALK2/3 Inhibitor -
HY-13011R
Alectinib (Standard)ALK Inhibitor -
HY-12857
BrigatinibALK Inhibitor -
HY-15609
AZD-3463ALK/IGF1R Inhibitor
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 1380575-43-8
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分子量 631.06
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分子式 C28H38Cl3N5O3S
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SMILES
CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3.[H]Cl.[H]Cl
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別名
LDK378 dihydrochloride (Standard)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013, Jun 6. [Content Brief]
[2]. Rothschild SI. Ceritinib-a second-generation ALK inhibitor overcoming resistance in ALK-rearranged non-small celllung cancer. Transl Lung Cancer Res. 2014 Dec;3(6):379-81. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ceritinib dihydrochloride (Standard) 関連分類
HY-15656AR 関連分類
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