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United States

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製品番号: HY-103052

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CGS-9896

CGS-9896 is an orally active benzodiazepine receptor agonist that targets the benzodiazepine receptor allosterically coupled to the GABA_A receptor and chloride ion carrier channel. The K_i value of CGS-9896 for benzodiazepine receptors in rats is 0.83 nM. CGS-9896 inhibits pentylenetetrazol-induced convulsions in mice and exerts an anticonvulsant effect.

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CAS 番号: 77779-36-3
分子式: C₁₆H₁₀ClN₃O
分子量:295.73

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CGS-9896 構造式

CAS 番号: 77779-36-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

CGS-9896 (1.17 mg/kg; p.o.) acts an ED₅₀ of 1.17 mg/kg p.o. for preventing pentylenetetrazole-induced convulsions in male mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male mice^[1]
Dosage:

1.17 mg/kg
Administration:

p.o.
Result:

Exhibited agonist (anticonvulsant) activity with an ED₅₀ of 1.17 mg/kg, representing the dose required to prevent tonic convulsions and death in 50% of treated mice.

化学情報

CAS 番号 77779-36-3
性状 Solid
分子量 295.73
分子式 C₁₆H₁₀ClN₃O
Color Light yellow to yellow
SMILES

O=C1C2=CNC=3C=CC=CC3C2=NN1C4=CC=C(Cl)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Takada S, et al.. Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. Journal of medicinal chemistry. 1996 Jul 05;39(14):2844-51. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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