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United States

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製品番号: HY-111781

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Civorebrutinib

(別名: WS-413)

Civorebrutinib (WS-413) is a selective, orally active BTK and TEC inhibitor with an IC₅₀ of <100 nM for both targets. Civorebrutinib inhibits B cell activation. Civorebrutinib significantly suppresses the in vivo growth of diffuse large B-cell lymphoma cells. Civorebrutinib can be used for the research of diffuse large B-cell lymphoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2155853-43-1
分子式: C₂₃H₂₂ClN₇O₂
分子量:463.92

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Civorebrutinib 構造式

CAS 番号: 2155853-43-1

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Civorebrutinib (1 h) exerts weak or no inhibitory effect on T cell activation, with an IC₅₀ >4000 nM [1].
Civorebrutinib (30 min) inhibits the activation of B cells in whole blood, with an IC₅₀ of <200 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Civorebrutinib (25-50 mg/kg; p.o.; once daily/twice daily; 21 days) exhibits potent in vivo anti-tumor activity against diffuse large B-cell lymphoma TMD-8 xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD.SCID (immunocompromised, TMD-8 cells implanted subcutaneously)^[1]
Dosage:

30 mg/kg; 25 mg/kg; 50 mg/kg
Administration:

p.o.; daily; 21 days; p.o.; twice daily; 21 days
Result:

Significantly suppressed the growth of TMD-8 tumors in vivo, with tumor volume substantially lower than the vehicle control and comparable to the positive control Ibrutinib at 30 mg/kg daily.
Showed potent tumor growth inhibition, with tumor volumes remaining at low levels similar to ibrutinib groups at 25 mg/kg twice daily and 50 mg/kg daily.

化学情報

CAS 番号 2155853-43-1
分子量 463.92
分子式 C₂₃H₂₂ClN₇O₂
SMILES

ClC(C=C1)=CN=C1OC2=CC=C(C3=NN([C@@H]4CCC5(CC5)N(C#N)C4)C(N)=C3C(N)=O)C=C2
別名

WS-413
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wu Y, et al. 5-Aminopyrazole carboxamide derivative as BTK inhibitor and its preparation. World Intellectual Property Organization, WO2017198050 A1 2017-11-23.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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