Clemastanin B
Based on 1 publication(s) in Google Scholar
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.71%
- CAS 番号: 112747-98-5
- 分子式: C32H44O16
- 分子量:684.68
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Clemastanin B
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生物活性
Clemastanin B inhibits different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian influenza viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC50 0.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV)[1].
Clemastanin B (0.05, 0.1, 0.2, 0.4 mg/ml; for 8 hours) treatment results in nucleoprotein (NP) distribution in the nuclei in MDCK cells[1].
Clemastanin B (48-72 h) after virus incubation (MOI, 0.01; for 2 h) causes a pronounced titer reduction of progeny virus in MDCK cells[1].
Clemastanin B (pre-incubated for 2 h) has no protective effect on MDCK cell lines with influenza virus[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 112747-98-5
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性状 Solid
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分子量 684.68
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分子式 C32H44O16
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Color White to light yellow
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SMILES
OC[C@@H]1[C@](C2=CC(OC)=C(C=C2)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)([H])OC[C@@H]1CC4=CC(OC)=C(C=C4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO
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別名
Clemastanin B
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
溶剤 & 溶解度
H2O : 50 mg/mL (73.03 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Zifeng Yang, et al. Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro. Int J Mol Med. 2013 Apr;31(4):867-73. [Content Brief]
[2]. Ping Xiao, et al. Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis). J Tradit Chin Med. 2016 Jun;36(3):369-76. [Content Brief]
[3]. Ping Xiao, et al. In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion. J Ethnopharmacol. 2014 Nov 18;157:55-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4605 mL | 7.3027 mL | 14.6054 mL | 36.5134 mL |
| 5 mM | 0.2921 mL | 1.4605 mL | 2.9211 mL | 7.3027 mL | |
| 10 mM | 0.1461 mL | 0.7303 mL | 1.4605 mL | 3.6513 mL | |
| 15 mM | 0.0974 mL | 0.4868 mL | 0.9737 mL | 2.4342 mL | |
| 20 mM | 0.0730 mL | 0.3651 mL | 0.7303 mL | 1.8257 mL | |
| 25 mM | 0.0584 mL | 0.2921 mL | 0.5842 mL | 1.4605 mL | |
| 30 mM | 0.0487 mL | 0.2434 mL | 0.4868 mL | 1.2171 mL | |
| 40 mM | 0.0365 mL | 0.1826 mL | 0.3651 mL | 0.9128 mL | |
| 50 mM | 0.0292 mL | 0.1461 mL | 0.2921 mL | 0.7303 mL | |
| 60 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.6086 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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