CP-94707
CP-94707 is an HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) inhibitor, with an IC50 of 4 μM against wild-type and HIV-1 reverse transcriptase Y181I-Y188L double mutant enzymes, and an IC50 of 10 μM against HIV-1 reverse transcriptase K103N mutant enzyme. CP-94707 inhibits the initiation of negative-strand DNA synthesis primed by tRNALys-3, as well as the elongation of DNA synthesis mediated by HIV-1 reverse transcriptase. CP-94707 can be used in studies related to HIV infection.
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- CAS 番号: 343250-05-5
- 分子式: C21H16N4OS
- 分子量:372.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
CP-94,707 (0.10-32 μM; 45 min) inhibits tRNALys-3-primed initiation activity of wild-type HIV-1 RT with an IC50 of 4 μM, retains full activity against Y181I-Y188L double mutant HIV-1 RT (IC50 = 4 μM), and shows only 2.5-fold reduced activity against K103N single mutant HIV-1 RT (IC50 = 10 μM)[1].
CP-94,707 (0.10-32 μM) inhibits elongation activity of wild-type HIV-1 RT with an IC50 of 4 μM, demonstrating no selectivity for initiation over elongation steps[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 343250-05-5
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分子量 372.44
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分子式 C21H16N4OS
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SMILES
O=C1SC2=CC=CC=C2N1CC3=CC=C(N4C(C)=NC5=C4C=CN=C5)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CP-94707 関連分類
HY-120055 関連分類
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