CP-94707
CP-94707 is an HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) inhibitor, with an IC50 of 4 μM against wild-type and HIV-1 reverse transcriptase Y181I-Y188L double mutant enzymes, and an IC50 of 10 μM against HIV-1 reverse transcriptase K103N mutant enzyme. CP-94707 inhibits the initiation of negative-strand DNA synthesis primed by tRNALys-3, as well as the elongation of DNA synthesis mediated by HIV-1 reverse transcriptase. CP-94707 can be used in studies related to HIV infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 343250-05-5
- 分子式: C21H16N4OS
- 分子量:372.44
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
CP-94,707 (0.10-32 μM; 45 min) inhibits tRNALys-3-primed initiation activity of wild-type HIV-1 RT with an IC50 of 4 μM, retains full activity against Y181I-Y188L double mutant HIV-1 RT (IC50 = 4 μM), and shows only 2.5-fold reduced activity against K103N single mutant HIV-1 RT (IC50 = 10 μM)[1].
CP-94,707 (0.10-32 μM) inhibits elongation activity of wild-type HIV-1 RT with an IC50 of 4 μM, demonstrating no selectivity for initiation over elongation steps[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 343250-05-5
-
分子量 372.44
-
分子式 C21H16N4OS
-
SMILES
O=C1SC2=CC=CC=C2N1CC3=CC=C(N4C(C)=NC5=C4C=CN=C5)C=C3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Pata JD, et al. Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jul 20;101(29):10548-53. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CP-94707 関連分類
HY-120055 関連分類
Powered by Bioz