Curcumin 5-8
Based on 1 Customer Validation
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.58%
- CAS 番号: 890984-26-6
- 分子式: C20H21NO4
- 分子量:339.39
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Autophagy Compound Library
HY-L029
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Orally Active Compound Library
HY-L061
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Cell Death Library
HY-L162
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Anti-Drug-Resistant Compound Library
HY-L169
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
1.09 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against B16 cell line
Inhibitory concentration for cytotoxic activity against B16 cell line
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[PMID: 15993583] |
| HUVEC | IC50 |
1.44 μg/mL
Compound: Entry 8
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Inhibitory concentration against human umbilical vein endothelial cells(HUVEC) growth
Inhibitory concentration against human umbilical vein endothelial cells(HUVEC) growth
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[PMID: 15993583] |
| SiHa | IC50 |
5.96 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against SiHa cell line
Inhibitory concentration for cytotoxic activity against SiHa cell line
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[PMID: 15993583] |
| U-87MG ATCC | IC50 |
8.31 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against U87 cell line
Inhibitory concentration for cytotoxic activity against U87 cell line
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[PMID: 15993583] |
| Vero | IC50 |
3.47 μg/mL
Compound: Entry 8
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Inhibitory concentration for cytotoxic activity against Vero cell line
Inhibitory concentration for cytotoxic activity against Vero cell line
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[PMID: 15993583] |
Curcumin 5-8 (20 µM; 24 h) decreases PA (palmitic acid (HY-N0830))-induced SREBP1 expression levels and increases Bcl2/BAX expression in AML12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AML12 cells
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Concentration:20 µM
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Incubation Time:24 h
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Result:Significantly decreased PA-induced SREBP1 expression levels, increased Bcl2/BAX expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old males, 20 g, C57BL/6 mice[1]
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Dosage:100 mg/kg
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Administration:Diet; daily for 13 weeks
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Result:Significantly suppressed the increases in the insulin level and HOMA-IR.
化学情報
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CAS 番号 890984-26-6
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性状 Solid
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分子量 339.39
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分子式 C20H21NO4
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Color Light yellow to yellow
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SMILES
O=C(C1=CC(NC(C(C)C)=O)=CC=C1)/C=C/C2=CC=C(C(OC)=C2)O
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別名
CUR5-8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (294.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9465 mL | 14.7323 mL | 29.4646 mL | 73.6616 mL |
| 5 mM | 0.5893 mL | 2.9465 mL | 5.8929 mL | 14.7323 mL | |
| 10 mM | 0.2946 mL | 1.4732 mL | 2.9465 mL | 7.3662 mL | |
| 15 mM | 0.1964 mL | 0.9822 mL | 1.9643 mL | 4.9108 mL | |
| 20 mM | 0.1473 mL | 0.7366 mL | 1.4732 mL | 3.6831 mL | |
| 25 mM | 0.1179 mL | 0.5893 mL | 1.1786 mL | 2.9465 mL | |
| 30 mM | 0.0982 mL | 0.4911 mL | 0.9822 mL | 2.4554 mL | |
| 40 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8415 mL | |
| 50 mM | 0.0589 mL | 0.2946 mL | 0.5893 mL | 1.4732 mL | |
| 60 mM | 0.0491 mL | 0.2455 mL | 0.4911 mL | 1.2277 mL | |
| 80 mM | 0.0368 mL | 0.1842 mL | 0.3683 mL | 0.9208 mL | |
| 100 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7366 mL |
Curcumin 5-8 関連分類
HY-148598 関連分類
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