DC-LC3in-D5
Based on 1 publication(s) in Google Scholar
DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy.
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- 純度: 98.62%
- CAS 番号: 2868312-73-4
- 分子式: C19H22Cl2N2O3
- 分子量:397.30
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Autophagy Compound Library
HY-L029
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Covalent Screening Library
HY-L036
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Cysteine Targeted Covalent Library
HY-L153
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Cell Death Library
HY-L162
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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High-Throughput Bioactive Compound Library
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MedChemExpress（MCE）の使用を引用している文献 DC-LC3in-D5
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生物活性
DC-LC3in-D5 demonstrates high selectivity to LC3A/B in the proteome. DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells[1].
Treatment of HeLa cells with DC-LC3in-D5 (3-30 μM) results in disruption of LC3B lipidation, inhibition of autophagic vesicle formation, and accumulation of p62[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:3, 10, 30 μM
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Incubation Time:16 hours
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Result:Pre-treated accumulated significant more p62 than DMSO-treated control samples. Attenuated LC3-I/II lipidation in cells exposed to autophagy inducing conditions.
化学情報
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CAS 番号 2868312-73-4
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性状 Solid
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分子量 397.30
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分子式 C19H22Cl2N2O3
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Color White to light yellow
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SMILES
O=C1/C(C(CC(C2=C(Cl)C(Cl)=CC=C2)C1)=O)=C/NCCN3CCOCC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
2026 Apr 2;189(7):1923-1941.e26. PMID: 41785850
溶剤 & 溶解度
DMSO : 35.71 mg/mL (89.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5170 mL | 12.5849 mL | 25.1699 mL | 62.9247 mL |
| 5 mM | 0.5034 mL | 2.5170 mL | 5.0340 mL | 12.5849 mL | |
| 10 mM | 0.2517 mL | 1.2585 mL | 2.5170 mL | 6.2925 mL | |
| 15 mM | 0.1678 mL | 0.8390 mL | 1.6780 mL | 4.1950 mL | |
| 20 mM | 0.1258 mL | 0.6292 mL | 1.2585 mL | 3.1462 mL | |
| 25 mM | 0.1007 mL | 0.5034 mL | 1.0068 mL | 2.5170 mL | |
| 30 mM | 0.0839 mL | 0.4195 mL | 0.8390 mL | 2.0975 mL | |
| 40 mM | 0.0629 mL | 0.3146 mL | 0.6292 mL | 1.5731 mL | |
| 50 mM | 0.0503 mL | 0.2517 mL | 0.5034 mL | 1.2585 mL | |
| 60 mM | 0.0419 mL | 0.2097 mL | 0.4195 mL | 1.0487 mL | |
| 80 mM | 0.0315 mL | 0.1573 mL | 0.3146 mL | 0.7866 mL |
DC-LC3in-D5 関連分類
HY-141882 関連分類
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