Dendrogenin A
Based on 1 Customer Validation
Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.7%
- CAS 番号: 1191043-85-2
- 分子式: C32H55N3O2
- 分子量:513.80
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.56 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| B16-F10 | IC50 |
0.68 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| HCT-8 | IC50 |
0.89 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| KG-1 | IC50 |
5.53 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| MCF7 | IC50 |
2.31 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| N2a | IC50 |
2.32 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| NB-4 | IC50 |
1.32 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| P19 | IC50 |
1.8 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| P19 | IC50 |
2.4 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay
Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay
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[PMID: 19821610] |
| SH-SY5Y | IC50 |
1.35 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| SK-MEL-28 | IC50 |
2.12 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| SK-N-SH | IC50 |
2.24 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| SW-620 | IC50 |
0.42 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| TS/A | IC50 |
1.28 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| U-87MG ATCC | IC50 |
0.74 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| U-937 | IC50 |
0.79 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| U-937 | IC50 |
0.8 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay
Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay
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[PMID: 19821610] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1191043-85-2
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性状 Solid
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分子量 513.80
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分子式 C32H55N3O2
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)NCCC4=CN=CN4)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C
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別名
DDA
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 30 mg/mL (58.39 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9463 mL | 9.7314 mL | 19.4628 mL | 48.6571 mL |
| 5 mM | 0.3893 mL | 1.9463 mL | 3.8926 mL | 9.7314 mL | |
| 10 mM | 0.1946 mL | 0.9731 mL | 1.9463 mL | 4.8657 mL | |
| 15 mM | 0.1298 mL | 0.6488 mL | 1.2975 mL | 3.2438 mL | |
| 20 mM | 0.0973 mL | 0.4866 mL | 0.9731 mL | 2.4329 mL | |
| 25 mM | 0.0779 mL | 0.3893 mL | 0.7785 mL | 1.9463 mL | |
| 30 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6219 mL | |
| 40 mM | 0.0487 mL | 0.2433 mL | 0.4866 mL | 1.2164 mL | |
| 50 mM | 0.0389 mL | 0.1946 mL | 0.3893 mL | 0.9731 mL |
Dendrogenin A 関連分類
HY-149132 関連分類
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