DKFZ-938
DKFZ-938 is a kallikrein-related peptidase 6 (KLK6) inhibitor, with an IC50 of 0.09 μM against human KLK6. DKFZ-938 binds to the catalytic serine residue in the active-site pocket of KLK6 and mimics the natural KLK6 substrate to inhibit the enzymatic activity of KLK6. DKFZ-938 can be conjugated to the non-canonical amino acid propargyllysine via copper-catalyzed azide-alkyne cycloaddition click chemistry. DKFZ-938 is used in research related to colorectal cancer and pancreatic cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C35H41N9O8
- 分子量:715.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
KLK6 0.09 μM (IC50) |
体外実験
DKFZ-938 (0-3000 nM; 30 min) exhibits potent covalent inhibitory activity against purified KLK6 in a cell-free biochemical assay, with an IC50 of 0.09 μM and a kinact/Ki of 1030 M-1s-1 [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 715.76
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分子式 C35H41N9O8
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SMILES
O=C(COC1=CC=C(N2C(C)=C(NC(COC(CC3=C(C)NC4=C3C=C(C#N)C=C4)=O)=O)C(C)=N2)C=C1)NCCOCCOCCOCCN=[N+]=[N-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DKFZ-938 関連分類
HY-189205 関連分類
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