Dns–LLC
Dns-LLC is a cell-permeable Cu+-selective fluorescent probe that forms a 1:1 complex with Cu+. The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu+ in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu+ in the Golgi apparatus.
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- CAS 番号: 3112200-59-3
- 分子式: C27H41N5O5S2
- 分子量:579.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Dns-LLC (10 μM) forms a 1:1 complex with Cu+ in buffered aqueous solution at physiological pH, exhibits approximately 12-fold fluorescence turn-on enhancement towards Cu+, and has a femtomolar-level binding affinity (Kd=12 fM)[1].
Dns-LLC (20 μM; 30 min) penetrates live human colorectal RKO cells, selectively detects intracellular Cu+ via a turn-on fluorescence response, localizes to the Golgi apparatus to detect Cu+ in this organelle, and exhibits no obvious cytotoxicity against RKO cells[1].
Dns-LLC holds potential for the study of cuproptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3112200-59-3
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分子量 579.77
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分子式 C27H41N5O5S2
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SMILES
CN(C)C(C1=CC=C2)=CC=CC1=C2S(=O)(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(N)=O)=O)=O)CC(C)C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dns–LLC 関連分類
HY-D3200 関連分類
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