country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-187386

Copy Link Print Information

dsNec-1

dsNec-1 is a radical-trapping antioxidant. dsNec-1 inhibits lipid peroxidation. dsNec-1 inhibits ferroptosis in mouse embryonic fibroblasts.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 200804-78-0
分子式: C₁₃H₁₁N₃OS
分子量:257.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

dsNec-1 構造式

CAS 番号: 200804-78-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

dsNec-1 is a radical-trapping antioxidant. dsNec-1 inhibits lipid peroxidation. dsNec-1 inhibits ferroptosis in mouse embryonic fibroblasts^[1].

体外実験

Oxidative StressFerroptosisNecroptosis

Oxidative Stress

dsNec-1 (200 μM; up to 6 h) potently inhibits lipid peroxidation in preoxidized egg Phosphatidylcholine (Phosphatidylcholines, egg) (HY-125854) liposomes, completely suppressing peroxidation with no induction period^[1].
dsNec-1 (8 μM; up to 6 h) acts as a radical-trapping antioxidant in native egg phosphatidylcholine liposomes, with a measured peroxyl radical-trapping rate constant of 5.5 M^-1s^-1^[1].

Ferroptosis

dsNec-1 (1 h prior to RSL3 (HY-100218A) treatment, total incubation including RSL3 of 12-16 h) potently suppresses RSL3-induced ferroptosis in Pfa1 mouse embryonic fibroblasts with an EC₅₀ of 0.67-1.2 μM^[1].

Necroptosis

dsNec-1 (5-50 μM; ~12 h) does not inhibit TNF/ZVAD.FMK-induced necroptosis in L929 mouse embryonic fibroblasts at concentrations up to 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

L929 mouse embryonic fibroblasts
Concentration:

5-50 μM
Incubation Time:

~12 h
Result:

Showed no ability to rescue cells from TNF/ZVAD.FMK-induced necroptosis at either 5 μM or 50 μM, with cell viability remaining near 0%.

Related Protocols :

Ferroptosis Solutions

化学情報

CAS 番号 200804-78-0
分子量 257.31
分子式 C₁₃H₁₁N₃OS
SMILES

S=C(N/C(C1=O)=C\C2=CNC3=CC=CC=C32)N1C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Al-Farhan A, et al. Suppression of Lipid Peroxidation by Necrostatins and Their Potential for Dual Targeting of Ferroptosis and Necroptosis. Journal of medicinal chemistry. 2026 Jul 23;69(14):17508-17523. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ