Ertabresib (Standard)
Ertabresib (Standard) (INCB-057643 (Standard)) is the analytical standard of Ertabresib (HY-111485). This product is intended for research and analytical applications. Ertabresib (INCB-057643) is an orally active BET protein inhibitor. Ertabresib blocks gene transcription by targeting the BET protein family, induces cell cycle arrest and apoptosis by downregulating proto-oncogenes such as c-MYC, and additionally reduces the expression of FOXP3 and PD-L1 to improve the immune microenvironment. It also exerts synergistic effects and overcomes drug resistance when combined with chemotherapy and XPO1 inhibitors. Ertabresib can be used in research related to high-grade B-cell lymphoma with MYC and BCL2 rearrangements, pancreatic cancer, pancreatitis, and metastatic castration-resistant prostate cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1820889-23-3
- 分子式: C20H21N3O5S
- 分子量:415.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 1820889-23-3
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分子量 415.46
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分子式 C20H21N3O5S
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SMILES
O=C1C(C)(C)OC2=C(C3=CN(C)C(C4=C3C=CN4)=O)C=C(S(=O)(C)=O)C=C2N1C
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別名
INCB-057643 (Standard)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ertabresib (Standard) 関連分類
HY-111485R 関連分類
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Keywords
- Ertabresib (Standard)
- 1820889-23-3
- INCB-057643 (Standard)
- Reference Standards
- Epigenetic Reader Domain
- Apoptosis
- c-Myc
- FOXP
- PD-1/PD-L1
- TP53
- pancreatitis
- high-grade B-cell lymphoma with MYC and BCL2 rearrangements
- BET protein
- pancreatic cancer
- RAW 264.7 macrophage-like cells
- MYC
- CD4 T cells
- BCL2
- metastatic castration-resistant prostate cancer
- Inhibitor
- inhibitor
- inhibit