FLQY2
FLQY2 is a camptothecin analog that exhibits outstanding antitumor efficacy against various solid tumors. FLQY2 possesses both in vitro and in vivo anti-pancreatic cancer activity, inhibiting cell proliferation, colony formation, inducing apoptosis, and causing cell cycle arrest at nanomolar concentrations.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 794512-88-2
- 分子式: C28H19F3N2O6
- 分子量:536.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
78.9 nM
Compound: FL77-20
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Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| HCT-116 | IC50 |
40.8 nM
Compound: FL77-20
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Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| HeLa | IC50 |
49.5 nM
Compound: FL77-20
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Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| HeLa | IC50 |
6.9 nM
Compound: 15 (table 1)
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Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
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[PMID: 15454230] |
| HepG2 | IC50 |
86.6 nM
Compound: FL77-20
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Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| MCF7 | IC50 |
47.1 nM
Compound: FL77-20
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Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| PC-3 | IC50 |
13.4 nM
Compound: 15 (table 1)
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Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
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[PMID: 15454230] |
化学情報
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CAS 番号 794512-88-2
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分子量 536.46
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分子式 C28H19F3N2O6
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SMILES
O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC6=C(OCO6)C=C5C(C7=CC=C(C(F)(F)F)C=C7)=C4CN31
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wang W, et al. Biological impact and therapeutic potential of a novel camptothecin derivative (FLQY2) in pancreatic cancer through inactivation of the PDK1/AKT/mTOR pathway[J]. Bioorganic Chemistry, 2024, 148: 107436. [Content Brief]
[2]. Wang Y, et al. Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability[J]. Journal of Nanobiotechnology, 2022, 20(1): 402. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FLQY2 関連分類
HY-162763 関連分類
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