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United States

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製品番号: HY-183582

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GB1841

GB1841 is an orally active and selective galectin inhibitor with human galectin-1 K_d of 0.027 μM, human galectin-3 K_d of 0.14 μM, mouse galectin-1 K_d of 0.034 μM and mouse galectin-3 K_d of 1.170 μM. GB1841 can be used for the research of lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2573135-33-6
分子式: C₁₈H₁₆BrClN₆O₄S₂
分子量:559.84

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

GB1841 構造式

CAS 番号: 2573135-33-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

Galectin-1

0.027 μM (Kd)

Galectin-3

0.14 μM (Kd)

Galectin アイソフォーム固有の製品をすべて表示 :

体外実験

GB1841 potently binds human galectin-1 (K_d 0.027 μM), human galectin-3 (K_d 0.14 μM), and human galectin-4C (K_d 0.25 μM); it also ^[1].
GB1841 potently binds mouse galectin-1 (K_d 0.034 μM) and mouse galectin-3 (K_d 1.170 μM)^[1].
GB1841 reduces A549 human lung adenocarcinoma cell viability by 62% at 90 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

GB1841 (30 mg/kg; p.o.; b.i.d. for 3 days) achieves free plasma levels sufficient for mouse galectin-1 inhibition for over 24 h, with a >90-fold therapeutic window relative to cell toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (female, 17−19 g, syngeneic implantation of LL/2 lung cancer cells)^[1]
Dosage:

30 mg/kg
Administration:

p.o.; b.i.d. for 3 days
Result:

Achieved free plasma Cmax levels of 1 μM.
Remained above the mouse galectin-1 K_d (0.034 μM) for over 24 h.
Did not reach levels above the mouse galectin-3 K_d (1.170 μM).
Demonstrated a >90-fold therapeutic window compared to cell toxicity levels (62% viability reduction at 90 μM in A549 cells).

化学情報

CAS 番号 2573135-33-6
分子量 559.84
分子式 C₁₈H₁₆BrClN₆O₄S₂
SMILES

O[C@@H]1[C@H](N2C=C(C3=NC(Cl)=CS3)N=N2)[C@@H](OC)[C@@H](SC4=C(C#N)N=CC(Br)=C4)O[C@@H]1CO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zetterberg FR, et al. An Orally Available Halothiazole Glycomimetic as a Cancer-Targeting Dual Galectin-1 and Galectin-3 Inhibitor. J Med Chem. 2026;69(9):10494-10514. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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