GB1841
GB1841 is an orally active and selective galectin inhibitor with human galectin-1 Kd of 0.027 μM, human galectin-3 Kd of 0.14 μM, mouse galectin-1 Kd of 0.034 μM and mouse galectin-3 Kd of 1.170 μM. GB1841 can be used for the research of lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2573135-33-6
- 分子式: C18H16BrClN6O4S2
- 分子量:559.84
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Galectin アイソフォーム固有の製品をすべて表示
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生物活性
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Galectin-1 0.027 μM (Kd) |
Galectin-3 0.14 μM (Kd) |
GB1841 potently binds human galectin-1 (Kd 0.027 μM), human galectin-3 (Kd 0.14 μM), and human galectin-4C (Kd 0.25 μM); it also [1].
GB1841 potently binds mouse galectin-1 (Kd 0.034 μM) and mouse galectin-3 (Kd 1.170 μM)[1].
GB1841 reduces A549 human lung adenocarcinoma cell viability by 62% at 90 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 17−19 g, syngeneic implantation of LL/2 lung cancer cells)[1]
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Dosage:30 mg/kg
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Administration:p.o.; b.i.d. for 3 days
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Result:Achieved free plasma Cmax levels of 1 μM.
Remained above the mouse galectin-1 Kd (0.034 μM) for over 24 h.
Did not reach levels above the mouse galectin-3 Kd (1.170 μM).
Demonstrated a >90-fold therapeutic window compared to cell toxicity levels (62% viability reduction at 90 μM in A549 cells).
化学情報
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CAS 番号 2573135-33-6
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分子量 559.84
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分子式 C18H16BrClN6O4S2
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SMILES
O[C@@H]1[C@H](N2C=C(C3=NC(Cl)=CS3)N=N2)[C@@H](OC)[C@@H](SC4=C(C#N)N=CC(Br)=C4)O[C@@H]1CO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GB1841 関連分類
HY-183582 関連分類
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