HENMT1 - HEN methyltransferase 1 Gene

Also Known as HEN1; C1orf59

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 113802

About HENMT1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,648,295-108,661,474 (from NCBI)

This gene has 7 transcripts (splice variants) and 199 orthologues. Biased expression in testis (RPKM 38.3), lymph node (RPKM 5.6) and 13 other tissues.

Summary

Enables small RNA 2'-O-methyltransferase. Involved in RNA methylation. Predicted to be located in P granule. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HENMT1 Products (2)

mRNA Protein Name
NM_001102592.2 NP_001096062.1 small RNA 2'-O-methyltransferase
NM_144584.3 NP_653185.2 small RNA 2'-O-methyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
22458338 GOA
enables small RNA 2'-O-methyltransferase activity IDA
IDA: Inferred from direct assay
11283698 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in RNA methylation IDA
IDA: Inferred from direct assay
11283698 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HENMT1 Protein Structure

Methyltransf_23

Methyltransf_23: Methyltransferase domain (35 - 191)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

small RNA 2'-O-methyltransferase

  • HEN1 methyltransferase homolog 1

HENMT1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
HENMT1 Q5T8I9 CCDC74B Homo sapiens Q96LY2-2
Validated Y2H
32296183
Intra
HENMT1 Q5T8I9 CCDC74B Homo sapiens Q96LY2-2
Y2H Prey Pooling
32296183
Intra
HENMT1 Q5T8I9 CCDC74B Homo sapiens Q96LY2-2
Y2H Array
32296183
Intra
HENMT1 Q5T8I9 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
HENMT1 Q5T8I9 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
HENMT1 Q5T8I9 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Cross
HENMT1 Q5T8I9 tax Human T-cell leukemia virus 1 P14079
Y2H Array
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06121 HENMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta HENMT1 VGNC VGNC:73241
Bos taurus HENMT1 VGNC VGNC:29809
Mus musculus HENMT1 MGD MGI:1913965
Rattus norvegicus HENMT1 RGD RGD:1306230
Felis catus HENMT1 VGNC VGNC:62795
Canis familiaris HENMT1 VGNC VGNC:41656
Others HENMT1 NCBI