DIS3L - DIS3 like exosome 3'-5' exoribonuclease Gene

Also Known as DIS3L1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 115752

About DIS3L

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,293,309-66,333,898 (from NCBI)

This gene has 14 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 25 other tissues.

Summary

The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of Other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

DIS3L Products (13)

mRNA	Protein	Name
NM_001143688.3	NP_001137160.1	DIS3-like exonuclease 1 isoform 1
NM_001323936.2	NP_001310865.1	DIS3-like exonuclease 1 isoform 2
NM_001323937.2	NP_001310866.1	DIS3-like exonuclease 1 isoform 5
NM_001323938.2	NP_001310867.1	DIS3-like exonuclease 1 isoform 3
NM_001323939.2	NP_001310868.1	DIS3-like exonuclease 1 isoform 3
NM_001323940.2	NP_001310869.1	DIS3-like exonuclease 1 isoform 4
NM_001323941.2	NP_001310870.1	DIS3-like exonuclease 1 isoform 3
NM_001323943.2	NP_001310872.1	DIS3-like exonuclease 1 isoform 4
NM_001323944.2	NP_001310873.1	DIS3-like exonuclease 1 isoform 6
NM_001323945.2	NP_001310874.1	DIS3-like exonuclease 1 isoform 2
NM_001323946.2	NP_001310875.1	DIS3-like exonuclease 1 isoform 3
NM_001323948.2	NP_001310877.1	DIS3-like exonuclease 1 isoform 7
NM_133375.5	NP_588616.1	DIS3-like exonuclease 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	20531389	GOA
enables 3'-5'-RNA exonuclease activity	IMP IMP: Inferred from mutant phenotype	20531386	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	20531386	GOA
enables exoribonuclease II activity	IDA IDA: Inferred from direct assay	37602378	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20531386	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in RNA catabolic process	IDA IDA: Inferred from direct assay	20531386	GOA
involved in RNA processing	IDA IDA: Inferred from direct assay	20531386	GOA
involved in rRNA catabolic process	IDA IDA: Inferred from direct assay	20531389	GOA
involved in rRNA catabolic process	IMP IMP: Inferred from mutant phenotype	20368444	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of cytoplasmic exosome (RNase complex)	IDA IDA: Inferred from direct assay	20531386	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20531386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIS3L Protein Structure

RNB

0
200
400
600
800
1000
1054 a.a.

Protein Preferred Names	Protein Names
DIS3-like exonuclease 1	DIS3 mitotic control homolog-like

DIS3L Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DIS3L	Q8TF46	EXOSC3	Homo sapiens	Q9NQT5	Anti Bait CoIP	20531386
Intra	DIS3L	Q8TF46	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	23756462
Intra	DIS3L	Q8TF46	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	33961781
Intra	DIS3L	Q8TF46	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Perlman Syndrome	Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor PRLMNS Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome Renal Hamartomas Nephroblastomatosis And Fetal Gigantism Nephroblastoma Fetal Macrosomia
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Trichohepatoenteric Syndrome 2	THES2
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03779	DIS3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03780	DIS3L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	DIS3L	MGD	MGI:2143272
Bos taurus	DIS3L	VGNC	VGNC:28073
Canis familiaris	DIS3L	VGNC	VGNC:39963
Macaca mulatta	DIS3L	VGNC	VGNC:71796
Rattus norvegicus	DIS3L	RGD	RGD:1308959
Felis catus	DIS3L	VGNC	VGNC:61500
Others	DIS3L	NCBI