Kat2b - K(lysine) acetyltransferase 2B Gene

Also Known as Pcaf; p/CAF; A930006P13Rik

生物種: Mus musculus

遺伝子タイプ: protein coding

遺伝子ID: 18519

About Kat2b

Chromosome 17: 53,873,889-53,979,748 forward strand.GRCm39:CM001010.3

This gene has 7 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 11 phenotypes. Ubiquitous expression in adrenal adult (RPKM 12.8), bladder adult (RPKM 11.9) and 28 other tissues.

Summary

Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in internal peptidyl-lysine acetylation and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of gluconeogenesis; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Kat2b Products (2)

mRNA	Protein	Name
NM_020005.4	NP_064389.2	histone acetyltransferase KAT2B isoform 1
NM_001190846.1	NP_001177775.1	histone acetyltransferase KAT2B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21402781	MGI
enables acetyltransferase activity	EXP EXP: Inferred from Experiment	11250901	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16245309	MGI
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	19773423	MGI
enables histone H3K9 acetyltransferase activity	IGI IGI: Inferred from genetic interaction	24051374	MGI
enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	9742083	MGI
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IDA IDA: Inferred from direct assay	18250163	MGI
enables peptide-lysine-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	21084751	MGI
enables peptide-lysine-N-acetyltransferase activity	IGI IGI: Inferred from genetic interaction	21084751	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9742083	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19773423	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	15509593	MGI

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of gluconeogenesis	IGI IGI: Inferred from genetic interaction	24051374	MGI
acts upstream of or within internal peptidyl-lysine acetylation	IGI IGI: Inferred from genetic interaction	24051374	MGI
involved in internal peptidyl-lysine acetylation	IMP IMP: Inferred from mutant phenotype	19773423	MGI
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19773423	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15509593	MGI
acts upstream of or within positive regulation of gluconeogenesis	IGI IGI: Inferred from genetic interaction	24051374	MGI
involved in positive regulation of glycolytic process	IDA IDA: Inferred from direct assay	21084751	MGI
involved in positive regulation of lipid biosynthetic process	IDA IDA: Inferred from direct assay	21084751	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15601857	MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose	IDA IDA: Inferred from direct assay	21084751	MGI

Cellular Component GO Annotation	Evidence	参考文献	由来
located in A band	IDA IDA: Inferred from direct assay	18250163	MGI
part of ATAC complex	IDA IDA: Inferred from direct assay	19936620	MGI
located in I band	IDA IDA: Inferred from direct assay	18250163	MGI
located in actomyosin	IDA IDA: Inferred from direct assay	18250163	MGI
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	9742083	MGI
located in kinetochore	IDA IDA: Inferred from direct assay	14519686	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	21084751	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15509593	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kat2b Protein Structure

PCAF_N

COG5076

Bromo_gcn5_like

0
200
400
600
813 a.a.

Protein Preferred Names	Protein Names
histone acetyltransferase KAT2B	histone acetylase PCAF histone acetyltransferase PCAF lysine acetyltransferase 2B p300/CBP-associated factor spermidine acetyltransferase KAT2B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-W015239	KAT8-IN-1		99.61%	Unkown
HY-173158	AUR1545	Inhibitor	99.58%	Unkown
HY-122822	GSK699		98.80%	Unkown
HY-168428	CHI-KAT8i5		98.00%	Unkown
HY-181695	PROTAC KAT2A/B degrader-1	Degrader	/	Unkown
HY-RS07077	KAT2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07078	Kat2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07079	KAT2B Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Kat2b	NCBI	NCBI:8850