Apc - APC regulator of WNT signaling pathway Gene

Also Known as RATAPC

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 24205

About Apc

Primary_assembly 18: 25,864,222-25,922,696 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 90 phenotypes. Biased expression in Brain (RPKM 51.2), Lung (RPKM 138.6) and 9 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including axonal growth cone; cell body fiber; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with neuron projection and synapse. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Apc Products (1)

mRNA Protein Name
NM_012499.1 NP_036631.1 adenomatous polyposis coli protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables microtubule binding IDA
IDA: Inferred from direct assay
12610628 RGD
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
15670646 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9786987 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
19858196 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
22399805 RGD
involved in establishment or maintenance of cell polarity IDA
IDA: Inferred from direct assay
12610628 RGD
involved in negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
28948298 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
16303851 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
16688812 RGD
involved in regulation of glutamate metabolic process IDA
IDA: Inferred from direct assay
19858196 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
18945221 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11689703 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in axonal growth cone IDA
IDA: Inferred from direct assay
15670646 RGD
located in cell body fiber IDA
IDA: Inferred from direct assay
23001297 RGD
located in cell cortex IDA
IDA: Inferred from direct assay
18042042 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15670646 RGD
located in growth cone IDA
IDA: Inferred from direct assay
16303851 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
15670646 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
8638125 RGD
located in microtubule IDA
IDA: Inferred from direct assay
16767746 RGD
located in neuron projection terminus IDA
IDA: Inferred from direct assay
18042042 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8638125 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
18042042 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19858196 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
8638125 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Apc Protein Structure

Suppressor_APC

Suppressor_APC: pfam11414 (134 - 214)

ARM

ARM: smart00185 (347 - 399)

APC_rep

APC_rep: pfam18797 (400 - 473)

ARM

ARM: sd00043 (497 - 533)

ARM

ARM: smart00185 (537 - 578)

ARM

ARM: sd00043 (541 - 578)

ARM

ARM: sd00043 (588 - 620)

ARM

ARM: sd00043 (628 - 669)

ARM

ARM: smart00185 (674 - 714)

ARM

ARM: sd00043 (678 - 712)

Arm

Arm: pfam00514 (716 - 756)

ARM

ARM: sd00043 (720 - 756)

Arm_APC_u3

Arm_APC_u3: pfam16629 (757 - 1044)

APC_u5

APC_u5: pfam16630 (1061 - 1160)

APC_r

APC_r: pfam05923 (1281 - 1298)

APC_u9

APC_u9: pfam16633 (1307 - 1392)

APC_r

APC_r: pfam05923 (1662 - 1685)

APC_u13

APC_u13: pfam16634 (1687 - 1739)

SAMP

SAMP: pfam05924 (1741 - 1762)

APC_u14

APC_u14: pfam16635 (1771 - 1864)

APC_u15

APC_u15: pfam16636 (1898 - 1972)

SAMP

SAMP: pfam05924 (2059 - 2078)

APC_basic

APC_basic: pfam05956 (2250 - 2595)

EB1_binding

EB1_binding: pfam05937 (2697 - 2869)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2870 a.a.
Protein Preferred Names Protein Names

adenomatous polyposis coli protein

  • APC, WNT signaling pathway regulator

  • WNT signaling pathway regulator

  • adenomatosis polyposis coli

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-112968 Human protein C / Unkown

Pre-clinical Phase

Bioactive Molecules (17)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-124955 proTAME Inhibitor 98.20% Unkown
HY-110287 Apcin Inhibitor 99.62% Unkown
HY-130257 CP5V Degrader 99.31% Unkown
HY-13255 TAME Inhibitor 99.51% Unkown
HY-130841 Apcin-A Inhibitor 98.0% Unkown
HY-P1918 Activated Protein C (390-404), human 98.74% Unkown
HY-13255A TAME hydrochloride Inhibitor 98.14% Unkown
HY-122142A Pyr-​Pro-​Arg-​pNA (hydrochloride) Substrate 99.24% Unkown
HY-126016 MAI-400 Inhibitor / Unkown
HY-P1918A Activated Protein C (390-404), human TFA / Unkown
HY-116473 CFM-1 Antagonist / Unkown
HY-179012 CDC20/HSP90-IN-1 Inhibitor / Unkown
HY-172401 CDC20-IN-2 Inhibitor / Unkown
HY-182052 Ferroptosis inducer-16 Inhibitor / Unkown
HY-112968A Bovine Protein C / Unkown
HY-122142 Pyr-​Pro-​Arg-​pNA Substrate / Unkown
HY-W614725 Apcin-A monohydrochloride Inhibitor / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P992193 Anti-B7-H7 Antibody / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Apc NCBI NCBI:324