NOL11 - nucleolar protein 11 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 25926

About NOL11

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:67,717,936-67,744,531 (from NCBI)

This gene has 11 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in lymph node (RPKM 16.4), appendix (RPKM 14.1) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in maturation of SSU-rRNA and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Located in nucleolus. Part of t-UTP complex. [provided by Alliance of Genome Resources, Apr 2022]

NOL11 Products (2)

mRNA Protein Name
NM_001303272.2 NP_001290201.1 nucleolar protein 11 isoform 2
NM_015462.5 NP_056277.2 nucleolar protein 11 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
22916032 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in maturation of SSU-rRNA IMP
IMP: Inferred from mutant phenotype
22916032 GOA
involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
IMP: Inferred from mutant phenotype
22916032 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleolus IDA
IDA: Inferred from direct assay
22916032 GOA
part of t-UTP complex IDA
IDA: Inferred from direct assay
22916032 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOL11 Protein Structure

NUC205

NUC205: NUC205 domain (200 - 243)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
Protein Preferred Names Protein Names

nucleolar protein 11

NOL11 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
NOL11 Q9H8H0 UTP4 Homo sapiens Q969X6
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Alopecia, Neurologic Defects, And Endocrinopathy Syndrome

  • Ane Syndrome

  • ANES

  • Alopecia-Progressive Neurological Defect-Endocrinopathy Syndrome

  • Alopecia-Progressive Neurological Defect-Endocrinopathy

  • Endocrine System Diseases
Bowen-Conradi Syndrome

  • BWCNS

  • Bowen Hutterite Syndrome

  • Bowen-Conradi Hutterite Syndrome

  • Bowen Syndrome, Hutterite Type

  • Bowen Hutterite Syndrome, Formerly

  • Hutterite Syndrome

  • Bowen Syndrome Hutterite Type

  • Fetal Growth Retardation
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Treacher Collins Syndrome 1

  • Treacher Collins Syndrome

  • Mandibulofacial Dysostosis

  • Treacher Collins-Franceschetti Syndrome

  • Tcof

  • Tcs

  • Mfd1

  • Franceschetti-Klein Syndrome

  • TCS1

  • Franceschetti Syndrome

  • Franceschetti-Zwahlen-Klein Syndrome

  • Zygoauromandibular Dysplasia

  • Treacher-Collins Syndrome

  • Mandibulofacial Dysostosis Without Limb Anomalies

  • Bilateral And Symmetric Oto-Mandibular Dysplasia
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09412 NOL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus NOL11 MGD MGI:1916229
Canis familiaris NOL11 VGNC VGNC:43881
Bos taurus NOL11 VGNC VGNC:32155
Felis catus NOL11 VGNC VGNC:63851
Rattus norvegicus NOL11 RGD RGD:1584081
Macaca mulatta NOL11 VGNC VGNC:75247
Others NOL11 NCBI