Mag - myelin-associated glycoprotein Gene

Also Known as 1B236

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 29409

Summary

Enables carboxylic acid binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including Schmidt-Lanterman incisure; mesaxon; and myelin sheath adaxonal region. Is integral component of plasma membrane. Used to study middle cerebral artery infarction and sciatic neuropathy. Biomarker of nerve compression syndrome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Mag Products (1)

mRNA Protein Name
NM_017190.4 NP_058886.1 myelin-associated glycoprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ganglioside GT1b binding IDA
IDA: Inferred from direct assay
8995428 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11733546 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18381654 RGD
enables sialic acid binding IDA
IDA: Inferred from direct assay
8995428 RGD
enables sialic acid binding IMP
IMP: Inferred from mutant phenotype
19420245 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
23132925 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in cell adhesion IDA
IDA: Inferred from direct assay
8995428 RGD
involved in cell-cell adhesion via plasma-membrane adhesion molecules IMP
IMP: Inferred from mutant phenotype
9298990 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
16140204 RGD
involved in negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
9298990 RGD
involved in negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
19349915 RGD
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
15282288 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
9298990 RGD
involved in nervous system development IEP
IEP: Inferred from expression pattern
2464408 RGD
involved in positive regulation of astrocyte differentiation IDA
IDA: Inferred from direct assay
19349915 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
12838505 RGD
located in mesaxon IDA
IDA: Inferred from direct assay
12838505 RGD
located in myelin sheath adaxonal region IDA
IDA: Inferred from direct assay
375239 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
9298990 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin-associated glycoprotein

  • S-MAG (C-term.)

  • brain neuron cytoplasmic protein 3

  • sialic acid-binding Ig-like lectin 4a

  • siglec-4a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-D1498 Mag-Fluo-4 AM ≥96.0% Unkown
HY-136924 FP-Biotin 99.08% Unkown
HY-101898 Indo-1 AM 96% Unkown
HY-10865 LY2183240 Inhibitor 98.04% Unkown
HY-P10369 Betiatide 98.72% Unkown
HY-112219A H3R antagonist 1 hydrochloride Inhibitor 99.10% Unkown
HY-112219 H3R antagonist 1 Inhibitor 99.21% Unkown
HY-D1700 Mag-indo-1/AM / Unkown
HY-D1701 Mag-Fura-2 AM / Unkown
HY-D1702 Mag-Fura-2 tetrapotassium / Unkown
HY-P11022 TL-119 Inhibitor / Unkown
HY-RS07963 MAG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07976 MAGED1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07977 MAGED2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W127843 Mag-Indo-1 tetrapotassium salt / Unkown
HY-179748 7.7 MAG / Unkown
HY-179749 7.9 MAG / Unkown
HY-179800 8.8 MAG / Unkown
HY-179801 8.7 MAG / Unkown
HY-180407 UGM-IN-1 Inhibitor / Unkown
HY-RS17016 Mag Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23459 Mag Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Mag NCBI NCBI:4099