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ISG20 - interferon stimulated exonuclease gene 20 Gene

Also Known as CD25; HEM45

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 3669

About ISG20

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,635,632-88,656,483 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 5 paralogues. Biased expression in lymph node (RPKM 12.2), spleen (RPKM 8.7) and 13 other tissues.

Summary

Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ISG20 Products (6)

mRNA	Protein	Name
NM_001303233.2	NP_001290162.1	interferon-stimulated gene 20 kDa protein isoform a
NM_001303234.2	NP_001290163.1	interferon-stimulated gene 20 kDa protein isoform a
NM_001303235.2	NP_001290164.1	interferon-stimulated gene 20 kDa protein isoform b
NM_001303236.2	NP_001290165.1	interferon-stimulated gene 20 kDa protein isoform b
NM_001303237.2	NP_001290166.1	interferon-stimulated gene 20 kDa protein isoform c
NM_002201.6	NP_002192.2	interferon-stimulated gene 20 kDa protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	11401564	GOA
enables U1 snRNA binding	IDA IDA: Inferred from direct assay	16514659	GOA
enables U2 snRNA binding	IDA IDA: Inferred from direct assay	16514659	GOA
enables U3 snoRNA binding	IDA IDA: Inferred from direct assay	16514659	GOA
enables exonuclease activity	IMP IMP: Inferred from mutant phenotype	21036379	GOA
enables single-stranded DNA 3'-5' DNA exonuclease activity	IDA IDA: Inferred from direct assay	11401564	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in DNA catabolic process	IDA IDA: Inferred from direct assay	11401564	GOA
involved in RNA catabolic process	IDA IDA: Inferred from direct assay	11401564	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	21036379	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	21036379	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	12594219	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Cajal body	IDA IDA: Inferred from direct assay	16514659	GOA
located in PML body	IDA IDA: Inferred from direct assay	9235947	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16514659	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16514659	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21036379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISG20 Protein Structure

RNase_T

0
100
181 a.a.

Protein Preferred Names	Protein Names
interferon-stimulated gene 20 kDa protein	estrogen-regulated transcript 45 protein

関連疾患

Diseases	Alias
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Estrogen-Receptor Positive Breast Cancer
Subacute Delirium	Delirium Acute Confusional State Nos
Yellow Fever	Urban Yellow Fever Jungle Yellow Fever Sylvatic Yellow Fever Yf Yellow Fever, Sylvan Bronze John Yellow Jack Yf- [Yellow Fever] Febris Flava
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-125980	LX-3	Inhibitor	98.08%	Unkown
HY-RS06930	ISG20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20043	Isg20 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26546	Isg20 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	ISG20	VGNC	VGNC:67833
Bos taurus	ISG20	VGNC	VGNC:30294
Macaca mulatta	ISG20	VGNC	VGNC:73769
Canis familiaris	ISG20	VGNC	VGNC:42107
Mus musculus	ISG20	MGD	MGI:1928895
Rattus norvegicus	ISG20	RGD	RGD:1306407
Others	ISG20	NCBI