NDN - necdin, MAGE family member Gene

Also Known as PWCR; HsT16328

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 4692

About NDN

Cytogenetic location: 15q11.2 Genomic coordinates (GRCh38): 15:23,685,400-23,687,305 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 161 orthologues, 37 paralogues and is associated with 5 phenotypes.

Summary

This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]

NDN Products (1)

mRNA Protein Name
NM_002487.3 NP_002478.1 necdin

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
21364888 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDN Protein Structure

MAGE

MAGE: MAGE family (105 - 275)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
Protein Preferred Names Protein Names

necdin

  • Prader-Willi syndrome chromosome region

NDN Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
NDN Q99608 EID1 Homo sapiens Q9Y6B2
Y2H Array
24722188
Intra
NDN Q99608 SYAP1 Homo sapiens Q96A49
BioID
32529326
Intra
NDN Q99608 PAIP2 Homo sapiens Q9BPZ3
BioID
32529326
Intra
NDN Q99608 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
NDN Q99608 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
NDN Q99608 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
NDN Q99608 TP53 Homo sapiens P04637
Y2H Array
24722188
Intra
NDN Q99608 NEFL Homo sapiens P07196
Y2H Array
24722188
Intra
NDN Q99608 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
NDN Q99608 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
NDN Q99608 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
NDN Q99608 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
NDN Q99608 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
NDN Q99608 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Prader-Willi Syndrome Due To Paternal Deletion Of 15q11q13 Type 1
Prader-Willi Syndrome Due To Paternal Deletion Of 15q11q13 Type 2
Angelman Syndrome

  • AS

  • Happy Puppet Syndrome

  • Happy Puppet Syndrome, Formerly

  • Puppetlike Syndrome
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Schaaf-Yang Syndrome

  • Prader-Willi-Like Syndrome

  • Chitayat-Hall Syndrome

  • SHFYNG

  • Pwls

  • Magel2-Related Prader-Willi-Like Syndrome

  • Magel2-Related Pwls

  • Arthrogryposis, Distal, With Hypopituitarism, Mental Retardation, And Facial Anomalies

  • Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial A

  • Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial Anomalies

  • Pws Due To A Point Mutation

  • Pws Due To Point Mutation

  • Prader-Willi Syndrome Due To A Point Mutation

  • Prader-Willi Syndrome Due To Point Mutation

  • Pws-Like
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Chromosomal Disease

  • Chromosomal Disorders

  • Congenital Chromosomal Disease
Central Precocious Puberty

  • Cpp

  • Gonadotropin-Dependant Precocious Puberty

  • Gonadotropin-Dependent Precocious Puberty

  • Precocious Puberty, Central
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Temple Syndrome

  • Uniparental Disomy, Maternal, Chromosome 14

  • Temple Syndrome Due To Paternal 14q32.2 Microdeletion

  • Paternal Del(14)(Q32.2)

  • Temple Syndrome Due To Paternal 14q32.2 Hypomethylation

  • Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14

  • Upd(14)Mat
Silver-Russell Syndrome 1

  • Silver-Russell Syndrome

  • Russell-Silver Syndrome

  • Silver-Russell Dwarfism

  • Rss

  • SRS1

  • Srs

  • Silver Russell Dwarfism

  • Russell Silver Syndrome

  • Silver Russell Syndrome
Beckwith-Wiedemann Syndrome

  • Wiedemann-Beckwith Syndrome

  • BWS

  • Exomphalos-Macroglossia-Gigantism Syndrome

  • Emg Syndrome

  • Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

  • Emg Abnormality

  • Wbs

  • Exomphalos Macroglossia Gigantism Syndrome

  • Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

  • Macroglossia Exomphalos Gigantism
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09110 NDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus NDN VGNC VGNC:68434
Macaca mulatta NDN VGNC VGNC:75149
Mus musculus NDN MGD MGI:97290
Bos taurus NDN VGNC VGNC:31936
Canis familiaris NDN VGNC VGNC:43675
Rattus norvegicus NDN RGD RGD:1310526
Others NDN NCBI