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THBS3 - thrombospondin 3 Gene

Also Known as TSP3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 7059

About THBS3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,195,588-155,209,178 (from NCBI)

This gene has 11 transcripts (splice variants), 238 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 9.2), gall bladder (RPKM 7.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

THBS3 Products (15)

mRNA	Protein	Name
NM_001252607.2	NP_001239536.1	thrombospondin-3 isoform 2 precursor
NM_001252608.2	NP_001239537.1	thrombospondin-3 isoform 3 precursor
NM_001407487.1	NP_001394416.1	thrombospondin-3 isoform 4 precursor
NM_001407488.1	NP_001394417.1	thrombospondin-3 isoform 5 precursor
NM_001407490.1	NP_001394419.1	thrombospondin-3 isoform 6
NM_001407554.1	NP_001394483.1	thrombospondin-3 isoform 7 precursor
NM_001407555.1	NP_001394484.1	thrombospondin-3 isoform 8 precursor
NM_001407556.1	NP_001394485.1	thrombospondin-3 isoform 9
NM_001407557.1	NP_001394486.1	thrombospondin-3 isoform 9
NM_001407558.1	NP_001394487.1	thrombospondin-3 isoform 10
NM_001407559.1	NP_001394488.1	thrombospondin-3 isoform 11
NM_001407560.1	NP_001394489.1	thrombospondin-3 isoform 12
NM_001407561.1	NP_001394490.1	thrombospondin-3 isoform 12
NM_001407562.1	NP_001394491.1	thrombospondin-3 isoform 14
NM_007112.5	NP_009043.1	thrombospondin-3 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables heparin binding	IDA IDA: Inferred from direct assay	8288588	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11943589	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THBS3 Protein Structure

COMP

EGF_CA

TSP_3

TSP_C

0
200
400
600
800
956 a.a.

Protein Preferred Names	Protein Names
thrombospondin-3

THBS3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	THBS3	P49746	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	THBS3	P49746	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	THBS3	P49746	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Pseudoachondroplasia	PSACH Pseudoachondroplastic Dysplasia Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome Spondyloepiphyseal Dysplasia, Pseudoachondroplastic Pseudoachondroplastic Spondyloepiphyseal Dysplasia Spondyloepiphyseal Dysplasia Pseudoachondroplastic
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency	BCKDKD Branched-Chain Ketoacid Dehydrogenase Kinase Deficiency Bckdk Deficiency Autism-Epilepsy Syndrome Due To Branched Chain Ketoacid Dehydrogenase Kinase Deficiency
Tracheal Calcification	Calcification Of Trachea
Pregnancy Adenoma	Lactating Adenoma
Multiple Epiphyseal Dysplasia	Med Polyepiphyseal Dysplasia Edm Epiphyseal Dysplasia, Multiple, 1 Epiphyseal Dysplasia, Multiple, 2 Epiphyseal Dysplasia, Multiple, 3 Epiphyseal Dysplasia, Multiple, 4 Epiphyseal Dysplasia, Multiple, 5 Epiphyseal Dysplasia, Multiple Edm1 Edm2 Edm3 Edm4 Edm5 Epiphyseal Dysplasia, Fairbank Type Epiphyseal Dysplasia, Ribbing Type Multiple Epiphyseal Dysplasia, Autosomal Dominant Multiple Epiphyseal Dysplasia, Autosomal Recessive Rmed Dysplasia, Epiphyseal, Multiple Osteochondrodysplasias
Alveolar Echinococcosis	Echinococcus Multilocularis Infection Echinococcosis Alveolococcosis Multilocular Hydatid Small Fox Tapeworm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14481	THBS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22858	Thbs3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29372	Thbs3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	THBS3	RGD	RGD:1596780
Mus musculus	THBS3	MGD	MGI:98739
Macaca mulatta	THBS3	VGNC	VGNC:78345
Bos taurus	THBS3	VGNC	VGNC:35830
Canis familiaris	THBS3	VGNC	VGNC:47337
Felis catus	THBS3	VGNC	VGNC:66156
Others	THBS3	NCBI