SCRT2 - scratch family transcriptional repressor 2 Gene

Also Known as ZNF898B

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 85508

About SCRT2

This gene has 1 transcript (splice variant), 104 orthologues and 36 paralogues. Low expression observed in reference dataset.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of neuron migration. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SCRT2 Products (1)

mRNA Protein Name
NM_033129.4 NP_149120.1 transcriptional repressor scratch 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCRT2 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (155 - 177)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (187 - 208)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (227 - 250)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (254 - 278)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

transcriptional repressor scratch 2

  • scratch 2 protein

関連疾患

Diseases Alias
Retinitis Pigmentosa 58

  • RP58

  • Retinitis Pigmentosa, Type 58
Metaphyseal Chondrodysplasia, Schmid Type

  • MCDS

  • Schmid Metaphyseal Chondrodysplasia

  • Metaphyseal Chondrodysplasia Schmid Type

  • Spondylometaphyseal Dysplasia, Japanese Type

  • Japanese Type Spondylometaphyseal Dysplasia

  • Schmid Type Metaphyseal Dysplasia

  • Metaphyseal Chondrodysplasia Type Schmid

  • Schmid Type Metaphyseal Chondrodysplasia

  • SMCD

  • Chondrodysplasia, Metaphyseal, Schmid Type

  • Corneal Dystrophy, Subepithelial Mucinous
Limited Scleroderma

  • Limited Cutaneous Systemic Sclerosis

  • Limited Systemic Sclerosis

  • Systemic Sclerosis Sine Scleroderma

  • Crest Syndrome

  • Limited Cutaneous Systemic Scleroderma

  • Scleroderma, Limited

  • Systemic Sclerosis, Limited

  • Progressive Systemic Sclerosis Sine Scleroderma

  • Scleroderma, Sine

  • Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

  • Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12566 SCRT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus SCRT2 VGNC VGNC:64936
Mus musculus SCRT2 MGD MGI:2139287
Rattus norvegicus SCRT2 RGD RGD:1564796
Bos taurus SCRT2 VGNC VGNC:106918
Macaca mulatta SCRT2 VGNC VGNC:108033
Others SCRT2 NCBI