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SYS1 - SYS1 golgi trafficking protein Gene

Also Known as C20orf169; dJ453C12.4; dJ453C12.4.1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 90196

About SYS1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,361,949-45,376,798 (from NCBI)

This gene has 8 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 8.9), ovary (RPKM 6.7) and 25 other tissues.

Summary

SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by OMIM, Aug 2009]

SYS1 Products (3)

mRNA	Protein	Name
NM_001099791.3	NP_001093261.1	protein SYS1 homolog isoform b
NM_001197129.2	NP_001184058.1	protein SYS1 homolog isoform a
NM_033542.4	NP_291020.1	protein SYS1 homolog isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYS1 Protein Structure

SYS1

0
100
156 a.a.

Protein Preferred Names	Protein Names
protein SYS1 homolog	SYS1 Golgi-localized integral membrane protein homolog

SYS1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SYS1	Q8N2H4	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	SYS1	Q8N2H4	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	SYS1	Q8N2H4	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	SYS1	Q8N2H4	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	ELOVL5	Homo sapiens	Q9NYP7	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	ELOVL5	Homo sapiens	Q9NYP7	Y2H Array	32296183
Intra	SYS1	Q8N2H4	ELOVL5	Homo sapiens	Q9NYP7	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	SYS1	Q8N2H4	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	SYS1	Q8N2H4	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
Intra	SYS1	Q8N2H4	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
Intra	SYS1	Q8N2H4	MCFD2	Homo sapiens	Q8NI22	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	MCFD2	Homo sapiens	Q8NI22	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	MCFD2	Homo sapiens	Q8NI22	Y2H Array	32296183
Intra	SYS1	Q8N2H4	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	SYS1	Q8N2H4	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	SYS1	Q8N2H4	TNFSF14	Homo sapiens	O43557	Y2H Array	32296183
Intra	SYS1	Q8N2H4	TNFSF14	Homo sapiens	O43557	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	SYS1	Q8N2H4	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	SYS1	Q8N2H4	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	MRPS18B	Homo sapiens	Q9Y676	Y2H Array	32296183
Intra	SYS1	Q8N2H4	MRPS18B	Homo sapiens	Q9Y676	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	MRPS18B	Homo sapiens	Q9Y676	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SYS1	Q8N2H4	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SYS1	Q8N2H4	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Alkuraya-Kucinskas Syndrome	ALKKUCS Kiaa1109-Related Early Lethal Congenital Brain Malformations-Arthrogryposis Syndrome Arthrogryposis
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14105	SYS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	SYS1	VGNC	VGNC:97315
Canis familiaris	SYS1	VGNC	VGNC:54736
Mus musculus	SYS1	MGD	MGI:1913710
Rattus norvegicus	SYS1	RGD	RGD:1583224
Others	SYS1	NCBI