MTSS2 - MTSS I-BAR domain containing 2 Gene

Also Known as ABBA; ABBA1; IDDOF; ABBA-1; MTSS1L

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 92154

About MTSS2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,661,204-70,686,053 (from NCBI)

This gene has 3 transcripts (splice variants), 277 orthologues and 1 paralogue. Broad expression in brain (RPKM 49.9), endometrium (RPKM 14.9) and 19 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in activation of GTPase activity and cellular response to platelet-derived growth factor stimulus. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

MTSS2 Products (1)

mRNA Protein Name
NM_138383.3 NP_612392.1 protein MTSS 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables GTPase activator activity IDA
IDA: Inferred from direct assay
20875796 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
20875796 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
20875796 GOA
involved in cellular response to platelet-derived growth factor stimulus IDA
IDA: Inferred from direct assay
20875796 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in ruffle membrane IDA
IDA: Inferred from direct assay
20875796 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTSS2 Protein Structure

IMD

IMD: IRSp53/MIM homology domain (15 - 239)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
Protein Preferred Names Protein Names

protein MTSS 2

  • MTSS1-like protein

MTSS2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MTSS2 Q765P7 SCAF1 Homo sapiens Q9H7N4
Validated Y2H
32296183
Intra
MTSS2 Q765P7 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
32296183
Intra
MTSS2 Q765P7 ALAS1 Homo sapiens P13196
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Intellectual Developmental Disorder With Ocular Anomalies And Distinctive Facial Features

  • IDDOF
Hypotonia
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08821 MTSS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris MTSS2 VGNC VGNC:43494
Macaca mulatta MTSS2 VGNC VGNC:75019
Rattus norvegicus MTSS2 RGD RGD:1309731
Felis catus MTSS2 VGNC VGNC:63661
Mus musculus MTSS2 MGD MGI:3039591
Bos taurus MTSS2 VGNC VGNC:31753
Others MTSS2 NCBI