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製品番号: HY-188125

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Globo H

Globo H is a carbohydrate antigen belonging to the globo-series glycosphingolipids, and its non-reducing terminal tetrasaccharide fragment serves as the core epitope recognized by antibodies. Globo H is upregulated in a variety of human cancer tissues, and is also present in some normal fetal and adult epithelial tissues. Globo H can be used in cancer-related research.

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CAS 番号: 207384-96-1
分子式: C₃₈H₆₅NO₃₀
分子量:1015.91

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Globo H 構造式

CAS 番号: 207384-96-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体外実験

Globo H, in the forms of Globo H‑BSA and Globo H‑ceramide, binds strongly to mAb VK‑9. This antigen achieves optimal binding to mAb VK‑9 via its 4 non-reducing terminal sugar sequences, while internal α‑GalNAc linkage modifications reduce binding affinity. Mixed hemagglutination assays confirm that this antigen is highly expressed on the surface of MCF‑7 human breast cancer cells and binds strongly to mAb VK‑9. Immunocytochemical detection shows only weak binding to SK‑OV‑4 human ovarian cancer cells and T47D human breast cancer cells, with no binding observed in the other tested cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

Globo H (10 μg; s.c.; at 0, 1, 2, 22, and 35 weeks) when administered as globo H-KLH conjugate plus QS21 adjuvant elicits an antibody response that recognizes globo H structures, including those on human tumor cells in female CB6F1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 207384-96-1
分子量 1015.91
分子式 C₃₈H₆₅NO₃₀
SMILES

CC(N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O[C@@H]2[C@H]([C@H](O[C@@H]([C@@H]2O)CO)O[C@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@H]([C@@H]([C@H]4O)O)O)CO)CO)O)CO)O)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O)O[C@H]6[C@H]([C@@H]([C@@H]([C@@H](O6)C)O)O)O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kudryashov V, et al. Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate. Glycoconjugate journal. 1998 Mar;15(3):243-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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