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製品番号: HY-177872

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GQC-05

(別名: NSC 338258)

GQC-05 (NSC338258), Ellipticine (HY-15753) derivative, is potent and selective c-Myc G-quadruplex ( c-Myc G4) stabilizer with K_D values of 0.1-1.43 μM. GQC-05 can reduce Myc expression and induce cancer cells apoptosis. GQC-05 can be used for the research of cancer, such as Burkitt lymphoma.

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CAS 番号: 501662-77-7
分子式: C₂₁H₂₃N₃O
分子量:333.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

GQC-05 構造式

CAS 番号: 501662-77-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CA46	IC₅₀	13 μM Compound: GQC-05; 14	Cytotoxicity against human CA46 cells assessed as reduction in cell viability by MTS assay Cytotoxicity against human CA46 cells assessed as reduction in cell viability by MTS assay	[PMID: 33355454]
Raji	IC₅₀	2.6 μM Compound: GQC-05; 14	Cytotoxicity against human Raji cells assessed as reduction in cell viability by MTS assay Cytotoxicity against human Raji cells assessed as reduction in cell viability by MTS assay	[PMID: 33355454]

化学情報

CAS 番号 501662-77-7
分子量 333.43
分子式 C₂₁H₂₃N₃O
SMILES

CN(C)CCOC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
別名

NSC 338258
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Brown RV, et al. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem. 2011 Nov 25;286(47):41018-27. [Content Brief]

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モル濃度計算機

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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