Hedychenone
Based on 1 Customer Validation
Hedychenone (compound 3) is a labdane diterpene. Hedychenone can be isolated from the rhizomes of Hedychium yunnanense. Hedychenone against HeLa cell with IC50 value of 9.76 μg/ml.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.62%
- CAS 番号: 56324-54-0
- 分子式: C20H26O2
- 分子量:298.42
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
21.13 μg/mL
Compound: Hedychenone
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Cytotoxicity against human A375 cells after 24 hrs
Cytotoxicity against human A375 cells after 24 hrs
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[PMID: 20303755] |
| A549 | GI50 |
7.4 μM
Compound: 7
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Growth inhibition of human A549 cells by Sulforhodamine B assay
Growth inhibition of human A549 cells by Sulforhodamine B assay
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[PMID: 21106458] |
| A549 | IC50 |
33.12 μg/mL
Compound: Hedychenone
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Cytotoxicity against human A549 cells after 24 hrs
Cytotoxicity against human A549 cells after 24 hrs
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[PMID: 20303755] |
| CHO | IC50 |
8.2 μg/mL
Compound: Hedychenone
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Cytotoxicity against CHO cells after 24 hrs
Cytotoxicity against CHO cells after 24 hrs
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[PMID: 20303755] |
| HeLa | GI50 |
63.2 μM
Compound: 7
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Growth inhibition of human HeLa cells by Sulforhodamine B assay
Growth inhibition of human HeLa cells by Sulforhodamine B assay
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[PMID: 21106458] |
| HL-60 | IC50 |
17.68 μg/mL
Compound: Hedychenone
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Cytotoxicity against human HL60 cells after 24 hrs
Cytotoxicity against human HL60 cells after 24 hrs
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[PMID: 20303755] |
| MCF7 | GI50 |
14.9 μM
Compound: 7
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Growth inhibition of human MCF7 cells by Sulforhodamine B assay
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
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[PMID: 21106458] |
| MCF7 | IC50 |
19.41 μg/mL
Compound: Hedychenone
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Cytotoxicity against human MCF7 cells after 24 hrs
Cytotoxicity against human MCF7 cells after 24 hrs
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[PMID: 20303755] |
| SK-N-SH | GI50 |
11.6 μM
Compound: 7
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Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
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[PMID: 21106458] |
化学情報
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CAS 番号 56324-54-0
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性状 Solid
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分子量 298.42
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分子式 C20H26O2
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Color White to off-white
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SMILES
C[C@@]12[C@](C(C=C([C@@H]2/C=C/C3=COC=C3)C)=O)([H])C(C)(CCC1)C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (167.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (4.19 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
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- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3510 mL | 16.7549 mL | 33.5098 mL | 83.7745 mL |
| 5 mM | 0.6702 mL | 3.3510 mL | 6.7020 mL | 16.7549 mL | |
| 10 mM | 0.3351 mL | 1.6755 mL | 3.3510 mL | 8.3775 mL | |
| 15 mM | 0.2234 mL | 1.1170 mL | 2.2340 mL | 5.5850 mL | |
| 20 mM | 0.1675 mL | 0.8377 mL | 1.6755 mL | 4.1887 mL | |
| 25 mM | 0.1340 mL | 0.6702 mL | 1.3404 mL | 3.3510 mL | |
| 30 mM | 0.1117 mL | 0.5585 mL | 1.1170 mL | 2.7925 mL | |
| 40 mM | 0.0838 mL | 0.4189 mL | 0.8377 mL | 2.0944 mL | |
| 50 mM | 0.0670 mL | 0.3351 mL | 0.6702 mL | 1.6755 mL | |
| 60 mM | 0.0558 mL | 0.2792 mL | 0.5585 mL | 1.3962 mL | |
| 80 mM | 0.0419 mL | 0.2094 mL | 0.4189 mL | 1.0472 mL | |
| 100 mM | 0.0335 mL | 0.1675 mL | 0.3351 mL | 0.8377 mL |
Hedychenone 関連分類
HY-N4062 関連分類
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