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United States

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製品番号: HY-189797

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Insecticidal agent 46

Insecticidal agent 46 is a voltage-gated sodium channel (VGSC) modulator. Insecticidal agent 46 shifts fast inactivation gating toward hyperpolarization and impairs the fast inactivation gate. Insecticidal agent 46 can be used as an insecticide.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3119060-02-2
分子式: C₂₈H₂₂BrF₃N₂
分子量:523.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Insecticidal agent 46 構造式

CAS 番号: 3119060-02-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Sodium Channel アイソフォーム固有の製品をすべて表示 :

体外実験

Insecticidal agent 46 (LC-2) (12.5-200 μM; 24 h) shows low toxicity in HEK293T and Marc145 cells, with IC₅₀ values exceeding 200 μM^[1].
Insecticidal agent 46 (3 μM) shifts the fast inactivation V_1/2 of DmNa22 expressed in Xenopus laevis oocytes by 13.23 mV in the hyperpolarizing direction without affecting activation gating^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK293T and Marc145 cells
Concentration:

12.5, 25, 50, 100, 200 μM
Incubation Time:

24 h (compound incubation); 4 h (CCK-8 incubation)
Result:

Inhibited HEK293T and Marc145 cell proliferation with the following inhibition rates: at 200 μM, HEK293T 9.74%, Marc145 3.38%; at 100 μM, HEK293T 5.66%, Marc145 3.36%; at 50 μM, HEK293T 3.80%, Marc145 2.14%; at 25 μM, HEK293T 2.94%, Marc145 1.34%; at 12.5 μM, HEK293T 1.14%, Marc145 0.85%.
The IC₅₀ values of LC-2 against both mammalian cell types exceeded 200 μM.

体内実験

Insecticidal agent 46 (LC-2) (10 μg/mL; larval immersion; 24 h) exhibits insecticidal activity against Aedes aegypti larvae, and its toxicity to the pyrethroid-resistant Puerto Rico strain is higher than that to the susceptible Waco strain^[1].
Insecticidal agent 46 (feeding) exhibits insecticidal activity against second-instar larvae of Drosophila melanogaster w1118, with an LC₅₀ of 1.82 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3119060-02-2
分子量 523.39
分子式 C₂₈H₂₂BrF₃N₂
SMILES

FC(C1=CC=CC=C1C[N+]2=C(C3=CC=CC=C3)N(CC4=CC=CC=C4)C5=CC=CC=C52)(F)F.[Br-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Luo J, et al. Targeting Voltage-Gated Sodium Channels: Discovery of a Multi-Pest Insecticidal Activity Compound with Negative Cross-Resistance to Pyrethroid Resistance. J Agric Food Chem. 2026;74:28362-28372.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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