Ionizable lipid-1
Based on 1 publication(s) in Google Scholar
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.
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- 純度 : 98.0%
- CAS 番号: 2055939-68-7
- 分子式: C58H114N2O5
- 分子量:919.54
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Ionizable lipid-1
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生物活性
製品説明
体外実験
Ionizable lipid-1 can be protonated and positively charged at acidic pH. Ionizable lipid-1 electrostatically binds to negatively charged RNA molecules, thereby encapsulating RNA into nanoparticles. Ionizable lipid-1 will be protonated again once entering cells, interacts with the negatively charged endosome membrane. The interaction leads to the disruption of the endosome membrane, thereby releasing the RNA payload into the cytoplasm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 2055939-68-7
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性状 Liquid (Density: 0.914±0.06 g/cm3)
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分子量 919.54
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分子式 C58H114N2O5
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Color Colorless to light yellow
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SMILES
O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Ther
Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency. [Abstract]2024 Oct 2;32(10):3356-3371. PMID: 38981468
溶剤 & 溶解度
体外:
Ethanol : 100 mg/mL (108.75 mM; Need ultrasonic)
Methanol : 50 mg/mL (54.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol / Ethanol | 1 mM | 1.0875 mL | 5.4375 mL | 10.8750 mL | 27.1875 mL |
| 5 mM | 0.2175 mL | 1.0875 mL | 2.1750 mL | 5.4375 mL | |
| 10 mM | 0.1088 mL | 0.5438 mL | 1.0875 mL | 2.7188 mL | |
| 15 mM | 0.0725 mL | 0.3625 mL | 0.7250 mL | 1.8125 mL | |
| 20 mM | 0.0544 mL | 0.2719 mL | 0.5438 mL | 1.3594 mL | |
| 25 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0875 mL | |
| 30 mM | 0.0363 mL | 0.1813 mL | 0.3625 mL | 0.9063 mL | |
| 40 mM | 0.0272 mL | 0.1359 mL | 0.2719 mL | 0.6797 mL | |
| 50 mM | 0.0218 mL | 0.1088 mL | 0.2175 mL | 0.5438 mL | |
| Ethanol | 60 mM | 0.0181 mL | 0.0906 mL | 0.1813 mL | 0.4531 mL |
| 80 mM | 0.0136 mL | 0.0680 mL | 0.1359 mL | 0.3398 mL | |
| 100 mM | 0.0109 mL | 0.0544 mL | 0.1088 mL | 0.2719 mL |
Ionizable lipid-1 関連分類
HY-156630 関連分類
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