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製品番号: HY-111003

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Isothiafludine

(別名: NZ-4)

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Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.87%
CAS 番号: 960527-22-4
分子式: C₁₈H₁₈FN₃OS₂
分子量:375.48

保管条件:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Isothiafludine 構造式

CAS 番号: 960527-22-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	29 μM Compound: NZ-4; 10	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay	[PMID: 30594676]
HepG2 2.2.15	CC₅₀	50.4 μM Compound: II-8c; NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay	[PMID: 32712535]
HepG2 2.2.15	CC₅₀	51.47 μM Compound: NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay	[PMID: 27484509]
HepG2 2.2.15	CC₅₀	59.2 μM Compound: II-8c; NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay	[PMID: 32712535]
HepG2 2.2.15	IC₅₀	50.4 μM Compound: NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay	[PMID: 27484509]

体外実験

Isothiafludine inhibits HBV DNA replication, with an IC₅₀ of 1.33 μM^[1].
Isothiafludine (8 days) shows an IC₅₀ (50% cytotoxicity) of 50.4 μM against HepG2.2.15 cells^[1].
Isothiafludine (1.25-20 μM, 48 h) also inhibits the replication of 3TC/ETV-dual-resistant and ADV-resistant HBV mutants in virus transfected Huh7 cells^[1].
Isothiafludine (10-20 μM, 8 days) decreases the levels of encapsidated HBV pgRNA in HepG2.2.15 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Isothiafludine (p.o., 25-100 mg/kg, for 15 days) inhibits DHBV DNA replication in a DHBV-infected duck model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DHBV-infected duck model^[2]
Dosage:

25-100 mg/kg
Administration:

p.o., for 15 days
Result:

Inhibited DHBV DNA in the sera on day 15.

化学情報

CAS 番号 960527-22-4
性状 Solid
分子量 375.48
分子式 C₁₈H₁₈FN₃OS₂
Color White to off-white
SMILES

O=C(C1=C(CC(C)C)SC(C2=NC=CS2)=N1)NCC3=CC=C(F)C=C3
別名

NZ-4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yang L, et al. Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation. Acta Pharmacol Sin. 2014 Mar;35(3):410-8. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Isothiafludine

MCE Bioactive Compound Library

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Isothiafludine 関連分類

HY-111003 関連分類