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製品番号: HY-182688

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ITYR-DBRMD

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1809339-61-4
分子式: C₁₃H₇Br₂I₂NO₅
分子量:670.82

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ITYR-DBRMD 構造式

CAS 番号: 1809339-61-4

容量

価格（税別）

在庫状況

数量

Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression^[1].

体外実験

ITYR-DBRMD (Compouund 5) (0.5 μM; 48 h) reduces cell viability in OVCAR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

OVCAR3 cells
Concentration:

0.5 μM
Incubation Time:

48 h
Result:

Reduced cell numbers by microscopy.

体内実験

ITYR-DBRMD (Compound 5) (5 mg/kg; i.c.v.; continuous infusion via osmotic minipump) reduces the latency to feed in the novelty suppressed feeding test in BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 8 weeks old)^[1]
Dosage:

5 mg/kg
Administration:

i.c.v.; continuous infusion via osmotic minipump
Result:

Reduced the latency to feed in the novelty suppressed feeding test.

化学情報

CAS 番号 1809339-61-4
分子量 670.82
分子式 C₁₃H₇Br₂I₂NO₅
SMILES

O=C(C(CC1=CC(I)=C(C(I)=C1)O)N2C(C(Br)=C(C2=O)Br)=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bernard Lerer, et al. Type iii deiodinase inhibitors and uses thereof. WO2015140792. 2016-09-16

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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